Manchester United will take on Real Sociedad in the Europa League, while fellow English side Arsenal will meet PSV Eindhoven in the group stage following the draw this afternoon.
United, who lifted Europe's second-tier club competition trophy in 2017, will also play Moldovan side Sheriff Tiraspol and Cypriot outfit Omonoia in Group E, who are managed by Neil Lennon.
Arsenal's other opponents in Group A include Bodo/Glimt and FC Zurich, as the two-times runners-up look to capture a maiden title in the competition.
Europa Conference League champions AS Roma were drawn with Shamrock Rovers' conquerors Ludogorets, Real Betis and HJK Helsinki.
The winners of the group stage, which begins on 8 September, will advance directly to the round of 16 that will take place from February onwards.
Group runners-up will progress to the knockout stage playoff round where they will meet one of eight teams that have finished third in their groups in the Champions League.
Third-placed teams in the Europa League groups will drop to the Europa Conference League where they will play the group runners-up from that event in the knockout round playoffs.
The Europa League final will take place at Budapest's Puskas Arena on 31 May next year.
Group A: Arsenal, PSV Eindhoven, Bodo/Glimt, FC Zurich
Group B: Dynamo Kyiv, Rennes, Fenerbahce, AEK Larnaca
Group C: Roma, Ludogorets, Real Betis, HJK Helsinki
Group D: Braga, Malmo, Union Berlin, Union Saint-Gilloise
Group E: Manchester United, Real Sociedad, FC Sheriff, Omonia Nicosia
Group F: Lazio, Feyenoord, FC Midtjylland, SK Sturm Graz
Group G: Olympiakos, Qarabag, Freiburg, Nantes
Group H: Red Star Belgrade, Monaco, Ferencvaros TC, Trabzonspor
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