Republic of Ireland international Adam Idah marked his return from a six-month injury lay-off with a goal, but Norwich City exited the Carabao Cup in the second round after a penalty shoot-out defeat to Bournemouth.
The 21-year-old needed surgery on a meniscus problem sustained in February and missed the remainder of a Premier League campaign that ended in relegation, and his 83rd-minute strike after coming off the bench looked to be the winner but for Brooklyn Genesini to pull Bournemouth level in stoppage time and secure a 2-2 draw to take the tie to penalties.
League Two side Crawley sent Fulham packing with a shock 2-0 win.
Kevin Betsy's side are languishing one place above the English Football League basement but goals from captain Tom Nichols and Liverpool loanee James Balagizi lifted them to a well-earned win over their Premier League opponents.
Issa Diop debuted for the Cottagers in a starting XI that was completely overhauled, with 10 changes from their weekend win over Brentford.
Marco Silva's men fell behind on 16 minutes, Ashley Nadesan feeding Nichols who sent a low, left-footed drive into the far corner.
The skipper then turned provider for Balagizi, who doubled the hosts' advantage four minutes into the second half.
Stockport forced Leicester into a penalty shootout after neither side could find a goal.
Daniel Iversen impressed on his Foxes debut, saving three penalties in a clash his side ultimately won 3-1 from the spot.
Two more ties were determined on penalties, with Lincoln edging out Barrow 3-1 and Gillingham emerging victorious in a tense battle with Exeter after a 6-5 shootout.
League Two hosts Stevenage looked to be heading in the same direction in their contest with League One opponents Peterborough until Jamie Reid's second-half stoppage-time heroics sent his side through.
Meanwhile MK Dons, who sit 22nd in the League One table, upset Championship side Watford in their 2-0 victory at Vicarage Road, Matthew Dennis and Darragh Burns netting either side of half-time to send their side through.
Aston Villa and Crystal Palace comfortably defeated their League One opponents, Odsonne Edouard and captain Luka Milivojevic sealing a 2-0 win over Oxford for the Eagles.
Bolton were level 1-1 with the Villans at the break, but Danny Ings' 63rd-minute penalty started a second-half rally that saw Lucas Digne and Leon Bailey put the game out of reach.
Everton advanced after a close 1-0 contest with League One side Fleetwood, while Nottingham Forest claimed a decisive 3-0 victory over Grimsby and Brentford beat Colchester 2-0.
Che Adams bagged a brace in Southampton's 3-0 win over Cambridge while League Two outfit Colchester could not find a way past Premier League opponents Brentford in a 2-0 loss.
Louie Sibley's strike on the 15-minute mark was all it took for Derby to dispatch West Brom, while the same scoreline decided Burnley, Charlton and Morecambe's victories over Shrewsbury, Walsall and Rotherham respectively.
Sheffield Wednesday advanced with a 3-0 win over Rochdale while James Waite struck in the winner in Newport County's 3-2 win over Portsmouth and Adama Traore ensured Wolves knocked out Preston with a 2-1 victory.
Elsewhere Blackburn bounced back from an early deficit to knock out Bradford, Bradley Dack answering Andy Cook's 18th-minute opener and Dilan Markanday netting the winner on 39 minutes.
