England could face Scotland or Wales at a World Cup for the first time after today's World Cup draw in Doha pitted the 2018 fourth-place finishers with the European play-off winners, Iran and the USA.
Wales will play the Scots or Ukraine in the play-off final, which has been delayed until June due to the Russian invasion of its neighbour.
England have never faced Scotland or Wales at a World Cup finals, but do have recent Euros experience against both of their neigbours.
Scotland faced England at Wembley in the group stage of Euro 2020 last June, while Wales and England came together at Euro 2016.
Iran and the US have a long history of political tension between their countries but have met before, the Iranians winning 2-1 in the group stages of World Cup 1998.
Hosts Qatar will kick off the tournament against Ecuador on 21 November, whilst elsewhere Group E pitted two former world champions Spain and Germany against each other.
Belgium take on fellow 2018 World Cup semi-finalists Croatia in Group F, while reigning champions France take on Denmark, Tunisia and the winner of intercontinental play-off one, which will be one of Australia, the United Arab Emirates and Peru.
England boss Gareth Southgate dismissed suggestions that uncertainty over one of their Group B opponents could affect preparations for the tournament.
Southgate told the BBC: "In this situation all our thoughts are with the people of Ukraine, so when this tie is played and how that is played out is irrelevant really.
"It's for the rest of us to adapt and adjust and provide them with the opportunity to play as and when they are able to."
"The first two teams (USA and Iran) we have not played for quite a while and the third is unknown but throws up a possible British derby – and we know what they are all about."
Wales caretaker boss Rob Page said of the potential clash with England on 29 November: "It is a mouth-watering tie. Scotland will be thinking the same, but our full focus is on getting there."
Former Scotland international James McFadden believes the prospect of facing England on the biggest stage will be a major motivation ahead of the play-offs.
"We have got play-offs that we have to worry about and hopefully we can get through the first one, which sets up an unbelievable encounter against Wales," the former Motherwell and Everton forward said.
"And then for either side, it’s a great incentive. It’s a big enough incentive in itself to get to the World Cup, but knowing that you’re going into a group again with England is great and I’m sure it will motivate the players going into those play-off games."
Group A Qatar, Netherlands, Senegal, Ecuador
Group B England, USA, Iran, Wales, Scotland or Ukraine
Group C Argentina, Mexico, Poland, Saudi Arabia
Group D France, Denmark, Tunisia, Australia or Peru
Group E Spain, Germany, Japan, Costa Rica or New Zealand
Group F Belgium, Croatia, Morocco, Canada
Group G Brazil, Switzerland, Serbia, CameroonGroup H Portugal, Uruguay, Korea Republic, Ghana