The Republic of Ireland will face world number one ranked Belgium in an Aviva Stadium friendly on Saturday, 26 March.
Stephen Kenny's men begin their Nations League against Ukraine in Dublin on Saturday 4 June, with the Belgium clash - and another Aviva match against Lithuania three days later - offering precious game time for the management and the squad ahead of the summer.
Kenny has said that Ireland's ambition is to win their Nations League group, which also includes Scotland and Armenia, so the spring will be an important double-header as they try to keep up the momentum gained from a positive end to the World Cup qualification campaign.
The FAI also confirmed Ireland will play two friendly fixtures in the November international window, with one of them in Dublin.
The visit of Roberto Martinez's Red Devils will be a big draw. The two countries last met at Euro 2016, when the supreme Belgians cruised to a 3-0 win in Bordeaux.
INTERNATIONAL FRIENDLIES (times TBC)
Republic of Ireland v Belgium, Saturday, 26 March, Aviva Stadium
Republic of Ireland v Lithuania, Tuesday, 29 March, Aviva Stadium