Everton's Alex Iwobi was sent off just seven minutes after coming on as Nigeria crashed out of the Africa Cup of Nations following a 1-0 defeat to Tunisia in the round of 16.
Iwobi was dismissed after his yellow card for a challenge on Youssef Msakni was upgraded to red after a VAR check in the 64th minute.
The three-time AFCON winners were already trailing to Msakni's strike from distance two minutes after the restart, with the ball squirming through Maduka Okoye's grasp.
There was no way back for them with Tunisia advancing to a quarter-final date with Burkina Faso.
Nigeria's exit means a number of British clubs will be able to welcome back some key players to domestic action.
Kemar Roofe and Joe Aribo can return to Rangers in time for the Old Firm derby with Celtic while Kelechi Iheanacho and Wilfred Ndidi will head back to aid Leicester's push for European football.
Burkina Faso booked their last-eight spot with a 7-6 penalty shootout win over 10-man Gabon after it had ended 1-1 after 120 minutes.
Burkina Faso held off a gallant rearguard action from 10-man Gabon to advance to the Africa Cup of Nations quarter-finals with a 7-6 victory on penalties after a 1-1 draw in their last-16 tie in Limbe on Sunday.
Ismahila Ouedraogo netted the decisive kick to ensure they are the first side into the last eight after an incident-packed and energy sapping clash.
After Burkina Faso skipper Bertrand Traore scored early, 10-man Gabon took the match into extra time following a dramatic last-minute equaliser.
But in the end the Burkinabe held their nerve in a dramatic shootout to advance to a showdown with Tunisia.
Additional reporting: Reuters
