Barcelona against Napoli is the stand out tie in the Europa League play-offs.
The Spanish giants find themselves trying to keep alive their hopes of European football after finishing third in their Champions League group behind Bayern Munich and Benfica.
It is the first time since 2003-04, when Barcelona were in the UEFA Cup, that the Catalan club will not be in the knockout stages of the Champions League, a competition they have won five times.
Napoli, winners of the competition in 1989, progressed from a Europa League group which included Leicester, who they beat 3-2 in the final group game in Naples.
The competition's most successful club Sevilla were paired with Dinamo Zagreb.
Sevilla, who have won the title a record six times, will have added incentive to add to that tally with this season's final taking place at their Ramon Sanchez-Pizjuan Stadium.
Real Betis also see the final hosted in their home city and will play 2008 winners Zenit St Petersburg.
Scottish champions Rangers, who finished second in their Europa League group behind Lyon, will play Borussia Dortmund, while Porto, winners of the competition in 2003 and 2011, were drawn against Lazio.
Moldovan minnows Sheriff Tiraspol are in the knockout stages of a European competition for the first time in their history and will play Portuguese side Braga.
Atalanta face Olympiacos and RB Leipzig were drawn against Real Sociedad.
The ties are scheduled to take place in February, with the first legs on 17 and the return matches on 24.
Meanwhile in the Europa Conference League, Leicester City will play Danish side Randers.
Tottenham Hotspur are awaiting a decision from UEFA on their place in the draw. The English side or Dutch outfit Vitesse will take on Rapid Vienna.
Celtic have been handed a tough draw against FK Bodø/Glimt, the Norwegian side who famously beat Roma in the group stage.
