Fikayo Tomori, Ollie Watkins and Aaron Ramsdale have returned to the England squad as Harry Maguire and Trent Alexander-Arnold miss the World Cup qualifiers against Andorra and Hungary through injury.
The Three Lions sit top of Group I heading into the penultimate international camp of the year, with manager Gareth Southgate naming a 23-man selection for the double-header.
AC Milan defender Tomori has been included in the squad nearly two years on from winning his first and only cap in Kosovo - the Three Lions' final match before the pandemic led football to shut down.
Watkins returns for the first time since being cut from the provisional Euro 2020 squad, with uncapped Ramsdale back having been brought into the squad that reached the final following an injury to Dean Henderson.
Maguire and Alexander-Arnold drop out of the group for next month's internationals through injury while Patrick Bamford, Nick Pope and Jude Bellingham also miss out.
Phil Foden returns after missing the September triple-header through a foot complaint, but Mason Greenwood was again conspicuous by his absence.
Bellingham and Greenwood are both absent despite strong recent performances at club level, with Southgate saying the workloads of the teenagers must be carefully managed.
"They don't come as a pair but they're both in similar situations, they are young players with heavy workloads at the moment," he said. "I've spoken to both of them. Jude at the moment is playing a high level of matches with Champions League games, league games.
"As an 18-year-old he had a full season last season and then into the Euros with no break. We have to remember these lads are still physically growing, so when we talk about young player development we have to be really careful in how we handle them.
"These are two players we think can be really exciting for England's future. We don't want to overload them, we want to make sure we are making the right decisions with them."
Goalkeepers: Sam Johnstone (West Bromwich Albion), Jordan Pickford (Everton), Aaron Ramsdale (Arsenal).
Defenders: Conor Coady (Wolverhampton Wanderers), Reece James (Chelsea), Tyrone Mings (Aston Villa), Luke Shaw (Manchester United), John Stones (Manchester City), Fikayo Tomori (AC Milan), Kieran Trippier (Atletico Madrid), Kyle Walker (Manchester City).
Midfielders: Phil Foden (Manchester City), Jordan Henderson (Liverpool), Jesse Lingard (Manchester United), Mason Mount (Chelsea), Kalvin Phillips (Leeds United), Declan Rice (West Ham United).
Forwards: Jack Grealish (Manchester City), Harry Kane (Tottenham Hotspur), Bukayo Saka (Arsenal), Jadon Sancho (Manchester United), Raheem Sterling (Manchester City), Ollie Watkins (Aston Villa).