Tottenham came from behind to draw 2-2 in their opening Europa Conference League Group G game at Rennes, but it was a costly evening as they suffered more injury problems.
In their toughest looking assignment of the inaugural third-tier European club competition, they went ahead through Loic Bade's early own goal before the French team hit back either side of half-time through Flavian Tait and Gaetan Laborde.
Pierre-Emile Hojbjerg’s leveller earned Spurs a point, after a deflected cross from Republic of Ireland defender Matt Doherty fell into his path. But Steven Bergwijn and Lucas Moura limped off and with a Premier League match against Chelsea in 72 hours, their attacking numbers look short.
Son Heung-min is already facing a race against time to be fit with a calf injury while Giovani Lo Celso does not get back from his quarantine camp in Croatia until Saturday, leaving Nuno Espirito Santo with a headache.
Vitesse top that group after winning 2-0 at Mura, Sondre Tronstad and Danilho Doekhi getting on the scoresheet.
Tammy Abraham was among the scorers as Jose Mourinho's Roma got their group matches under way by coming from behind to thrash CSKA Sofia 5-1 at the Stadio Olimpico.
Dubliner Graham Carey gave the visitors the lead in the 10th minute before Lorenzo Pellegrini’s superb curling effort drew the contest level 15 minutes later.
Stephan El Shaarawy subsequently put Mourinho’s men in front with a 38th-minute strike, Pellegrini added their third just past the hour mark, and after CSKA then had Yanic Wildschut was sent off in the 80th minute, Gianluca Mancini and substitute Abraham, the summer signing from Chelsea, wrapped things up with efforts in the 82nd and 84th respectively.
Also in Group C, Bodo Glimt beat Zorya Luhansk 3-0 at home, with Ulrik Saltnes, Ola Solbakken and Amahl Pellegrino netting for the Norwegians before Artem Gromov’s late reply.
In Group A LASK won 2-0 at HJK Helsinki courtesy of goals from Dario Maresic and Christoph Monschein.
Gent opened their Group B campaign with a 1-0 win over the side that knocked Shamrock Rovers out in the play-off round, Flora Tallinn. Darko Lemajic’s second-half effort was the difference, while the other match in the pool saw Partizan Belgrade triumph 2-0 at Anorthosis Famagusta.
In Group D AZ Alkmaar were held to a 2-2 draw at Randers, and Cluj lost 1-0 at Jablonec, with Vaclav Pilar scoring a second-half penalty awarded for a handball by Camora, who was sent off.
Slavia Prague won 3-1 at home against 10-man Union Berlin in Group E following late goals from Jan Kuchta and Ivan Schranz.
In Group F, Jonas Wind notched a brace, the second a penalty, as FC Copenhagen won 3-1 at Slovan Bratislava, and on-loan Middlesbrough man Chuba Akpom scored for PAOK Salonika in their 2-0 victory at Lincoln Red Imps.
Both matches in Group H were 0-0 draws, between Qarabag and Basel, and Kairat Almaty and Omonia Nicosia.