Mason Greenwood sealed Ole Gunnar Solskjaer's side a point at Southampton as Manchester United equalled the top-flight's longest unbeaten away record.
United had a euphoric start to the season with a 5-1 home win over Leeds United but could not repeat that performance and were lucky not to lose to Ralph Hasenhuttl's organised and dynamic side.
Southampton took the lead on the half-hour mark after a bright spell when Jack Stephens dispossessed Bruno Fernandes in the United half and the hosts swiftly moved the ball towards Che Adams, whose shot took a heavy deflection off Fred to squirm inside the near post and past David de Gea.
United defender Harry Maguire had hit the crossbar early on with a looping header while Anthony Martial's rebound was scrambled off the line by Mohammed Salisu but the half had belonged to Southampton, who swarmed over United with an aggressive high press and caused havoc down the right hand side.
Ole Gunnar Solskjaer's side levelled early in the 55th when Greenwood thumped a low shot under Southampton keeper Alex McCarthy after clever interplay between Fernandes and Paul Pogba, who added another assist to the five he notched against Leeds.
Southampton finished the game strongest though and Adam Armstrong missed two clear chances to win it, first being denied by a fine save from De Gea following another speedy transition and then failing to steer an Adams flick on towards goal following a corner.
Bruno Fernandes was furious that Jack Stephens was not punished for a foul in the build-up, but his mood improved 10 minutes into the second half when Greenwood struck through a crowd.
United tapered off after a strong start to the second period, with summer signing Adam Armstrong having a couple of chances to fire Saints to a first home win against United since 2003.
James Ward-Prowse had the first effort of the game when forcing David De Gea into action with a long-range free-kick, but United settled and somehow failed to score seven minutes in.
Harry Maguire and Paul Pogba strained to reach a Fernandes set piece, with the ball looping onto the bar before Mohammed Salisu blocked Anthony Martial’s headed follow-up and impressive teenager Tino Livramento cleared.
Greenwood dragged wide from distance and Salisu blocked a Pogba strike as the visitors continued strongly, with the France midfielder then heading over a Luke Shaw free-kick.
Southampton were angered by a break in play after Moussa Djenepo accidentally caught Greenwood in the face, but it worked in their favour as it allowed them to regather their thoughts.
Armstrong bent over from the edge of the box following some Djenepo stepovers, with St Mary’s erupting in the 30th minute.
Fernandes was furious having felt he was fouled on the right by Stephens, who left the Portuguese in a heap and continued to fizz across to Djenepo. The winger’s first-time ball was smartly flicked on by Armstrong to Adams, who took a couple of touches and struck home from 20 yards via a deflection off Fred.
Fernandes was booked for his remonstrations with the officials after the goal and Saints threatened a second, with Livramento superbly bursting down the right only to just overhit a cross.
Alex McCarthy denied a close-range Nemanja Matic header shortly before half-time, which started with Southampton apologising to supporters and promising refunds after thousands of fans’ entry was delayed.
Jan Bednarek came on for Theo Walcott at the break as Saints went to a three-man backline, which was holding its breath when United appealed for handball after a Pogba effort struck Salisu.
Armstrong sent over a smart cross and Livramento lashed over at the other end, before United levelled in the 55th minute.
Pogba poked a Fernandes ball on to Greenwood, whose shot beat McCarthy and found the back of the net in front of the raucous travelling support.
Jadon Sancho replaced Anthony Martial and Pogba was soon leading the Southampton defence a merry dance before hitting a left-footed shot just across the face of goal.
Greenwood headed onto the roof of the net and McCarthy produced an unorthodox save to deny a Fernandes header.
Until that point De Gea had precious little to do but came to the rescue in the 73rd minute. Pressing Ward-Prowse took the ball off Maguire and Adams threaded through Armstrong to get a shot on goal.
The Saints new boy wasted a great chance shortly after when Adams glanced on a corner to him at the far post, but he failed to get a telling touch on it.
De Gea punched a Ward-Prowse free-kick clear as Saints ended the match on top to earn a deserved point.
