Real Madrid captain Sergio Ramos may have played his last game for the club after they announced on Saturday that he had picked up a hamstring injury.
Ramos's contract runs out at the end of June and there are only four La Liga games remaining this season.
"Following the tests carried out on Sergio Ramos by the Real Madrid Medical Services, he has been diagnosed with tendonitis in the muscle of his left hamstring. His recovery will continue to be assessed," Real said in a statement.
Real, who sit second in La Liga on 74 points, take on fourth-placed Sevilla - Ramos's former club - on Sunday in a pivotal weekend for the title race, with leaders Atletico facing Barcelona.
Injuries have plagued the 35-year-old this season, limiting him to 15 league starts and only five appearances in all competitions in 2021.
He has won five league titles and four Champions League titles since signing for Madrid in 2005, as well as the 2010 World Cup and two European Championships during a Spain career that has accumulated 180 caps thus far.
Meanwhile Real Madrid coach Zinedine Zidane has said he will make things easy for club, whatever they decide on his future at the end of the season.
The Frenchman, who has won three Champions League trophies and two La Liga titles in two spells as Real coach, could find his future under threat should Real end the season trophyless.
The La Liga champions were dumped out of the Copa del Rey by third tier Alcoyano in January and were defeated comfortably by Chelsea in their Champions League semi-final this week.
They are second in La Liga, two points behind Atletico Madrid, and require their city rivals to slip up if they are to stand a chance of retaining their crown.
"Let's just finish this season. What I will say is that I'll make things easy for the club, always, because they've always given me everything," Zidane told a news conference on Saturday.
"I'll make things very easy, but right now we are all focused on the four remaining games and ending the season well. That's what motivates me. All the rest is just talk."