Swansea climbed to third in the Sky Bet Championship after they beat Sheffield Wednesday 2-0 at Hillsborough.
Goals from Jamal Lowe and Jay Fulton saw Steve Cooper's side take a step closer to securing a play-off place, while the Owls remain 23rd and nine points adrift of safety.
Lowe broke the deadlock in the 31st minute with his third goal in two games. Ayew muscled Julian Borner off the ball and squared a pass across the face of goal for Lowe to tap in his 13th goal of the season.
Republic of Ireland duo Conor Hourihane and Ryan Manning both started for the victors, the pair linking up on the stroke of half-time to double Swansea's lead but the Galway man's curled shot just cleared the crossbar.
Swansea substitute Connor Roberts created the second goal for Fulton, who steered a bullet header past Westwood 60 seconds later.
Philip Billing scored against his former club as Bournemouth beat Huddersfield 2-1 in the Sky Bet Championship.
The in-form Cherries notched an impressive fifth straight league win as they appear to be heading menacingly towards the play-offs.
Jonathan Woodgate's side moved up to fifth in the table, five points ahead of seventh-placed Reading.
The Terriers, meanwhile, have now won just once in their last 10 matches and still have work to do to secure their second-tier status.
Billing and Dominic Solanke scored either side of the break for the visitors, Jonathan Hogg nodding home late to give the visitors hope but they couldn't rustle up an equaliser.
Rotherham received a boost in their bid to avoid the drop with a 3-1 win over QPR.
After a scoreless first half, Lyndon Dykes put the visitors in front of 52 minutes but Freddie Ladapo turned the tables, scoring two goals in three minutes after the hour mark.
As the west London outfit pushed for an equaliser late in the game, Rotherham broke away, Michael Smith sealing the win for the Millers with an expert finish in injury-time.