Aston Villa striker Ollie Watkins and West Brom goalkeeper Sam Johnstone have received their first senior England call-ups, but Liverpool's Trent Alexander-Arnold is a surprise omission.
Gareth Southgate has named a 26-man squad for this month's World Cup qualification triple-header against San Marino, Albania and Poland.
Leeds striker Patrick Bamford had been widely tipped for a call-up, but Southgate has turned to Watkins, who has impressed since joining Villa from Brentford in the summer.
Johnstone, who has shone for the embattled Baggies this season, gets his maiden call-up following an injury to England number one Jordan Pickford.
Borussia Dortmund's Jude Bellingham has also been called up despite concerns over his availability.
Alexander-Arnold however is conspicuous by his absence from a squad that sees Luke Shaw, John Stones and Jesse Lingard return after long absences.
Seventeen-year-old Bellingham's inclusion is interesting given the English Football Association had expected regional Covid-19 travel restrictions in Germany to rule him out.
Dortmund team-mate Jadon Sancho misses out through injury, while Jack Grealish, James Maddison and Tammy Abraham are not included having been dealing with issues of their own.
Speaking of the decision to leave out Alexander-Arnold, Southgate said: "I don't think he's played at the level he's been at during the last few years.
"He's a big talent and I'm sure he will play a big role for England in the future."
England squad:
Goalkeepers: Dean Henderson, Sam Johnstone, Nick Pope
Defenders: Ben Chilwell, Conor Coady, Eric Dier, Reece James, Harry Maguire, Tyrone Mings, Luke Shaw, John Stones, Kieran Trippier, Kyle Walker
Midfielders: Jude Bellingham, Phil Foden, Jesse Lingard, Mason Mount, Kalvin Phillips, Declan Rice, James Ward-Prowse
Forwards: Dominic Calvert-Lewin, Harry Kane, Marcus Rashford, Bukayo Saka, Raheem Sterling, Ollie Watkins