Chris Wilder has departed his role as Sheffield United manager by mutual consent, the club said in a statement this evening.
Wilder, 53, took charge of his boyhood club in 2016 after they finished 11th in League One (third tier).
He led them to two promotions in three years and their highest top-flight finish in 28 years.
United visit third-placed Leicester City on Sunday.
In the statement released on the Sheffield United website, Wilder commented: "Being manager of Sheffield United has been a special journey and one I'll never forget. I was delighted to be given the opportunity back in 2016 and have been delighted with the success which we have achieved, including two promotions and a highest ever Premier League finish.
"I'd like to thank everyone who has contributed to the Club's accomplishments along the way, including the players, staff and, in particular, the supporters."