Sheffield United secured their first win of the season as they reached the fourth round of the FA Cup with a 3-2 victory at Bristol Rovers.
Oliver Burke - with his first Blades goal since a September switch from West Brom - and Jayden Bogle added to an early Joe Day own goal as the Premier League's basement club led three times.
Rovers defenders Alfie Kilgour and Max Ehmer equalised from set-pieces for the Sky Bet League One hosts, but United held their nerve to finally win at the 19th attempt this season.
Brentford edged their way into the FA Cup fourth round with an entertaining 2-1 win over Middlesbrough.
Maiden goals for Brentford pair Halil Dervisoglu and Saman Ghoddos cancelled out Sam Folarin's reply, also his first in a Boro shirt.
Burnley avoided an FA Cup upset with a 4-3 penalty shoot-out victory over League One MK Dons at Turf Moor.
The Dons led through Cameron Jerome's 29th-minute header and looked set to beat a Premier League team in the competition for just the second time but Burnley substitute Matej Vydra grabbed an equaliser in the final minute of injury time to make it 1-1.
Dons manager Russell Martin was then sent to the stands and two periods of extra-time did not yield a goal.
Vydra saw his opening spot-kick saved by the excellent Lee Nicholls but Burnley's debutant keeper Will Norris proved the hero with stops from Lasse Sorensen and Ben Gladwin before Phil Bardsley rolled in the winning penalty.
Leicester advanced in comfortable fashion as the Premier League high-fliers beat Stoke 4-0 at the bet365 Stadium.
James Justin put the Foxes in front with a fine strike in the 34th minute, shortly after Sam Vokes had missed a good chance to give the Championship hosts the lead.
Marc Albrighton doubled the advantage with a 59th-minute finish, Ayoze Perez made it 3-0 with 11 minutes of normal time to go, and Harvey Barnes added a fourth two minutes later.
Sam Allardyce's wait for a first win in charge of West Brom will continue after the Baggies were dumped out of the FA Cup by Sky Bet League One Blackpool, losing a penalty shoot-out 3-2.
Seasiders captain Chris Maxwell, playing his first game since 19 December after testing positive for Covid-19, saved spot-kicks from Kyle Edwards, Darnell Furlong and Matheus Pereira to give Blackpool their first FA Cup win over top-flight opposition since they beat Burnley 1-0 45 years ago.
The match had finished 2-2 after 90 minutes, with West Brom needing a slightly fortuitous penalty from Pereira with 10 minutes left to extend the contest after Jerry Yates and Gary Madine struck either side of Semi Ajayi's equaliser.
Though Yates missed the opening penalty to hand West Brom the advantage, they could not take it as Maxwell saw his side through to the fourth round.
Plymouth reached the fourth round for the first time since 2008 by beating Huddersfield's second string 3-2 at the John Smith's Stadium.
Argyle skipper Joe Edwards struck the winner midway through the second half after the visitors had twice fallen behind against Carlos Corberan's makeshift side.
Romoney Crichlow and Aaron Rowe both scored their first senior goals for Huddersfield to twice give the West Yorkshire club the lead in the first period.
But Plymouth, promoted back to Sky Bet League One last season, responded each time through Ryan Hardie and Panutche Camara before Edwards struck their winner.
Substitutes Bobby Decordova-Reid and Neeskens Kebano fired Fulham into the FA Cup fourth round at the expense of QPR.
The Premier League outfit needed extra time to see off their west London neighbours 2-0, after Lyndon Dykes had missed a gilt-edged chance to win it for Championship Rangers.
Wycombe reached the FA Cup fourth round for only the third time in their history thanks to a dominant 4-1 win over Preston.
Goals from Fred Onyedinma, Joe Jacobson and Josh Knight had the Chairboys 3-0 up after just 25 minutes, before Emil Riis pulled one back from the penalty spot just short of half-time.
But Preston never looked like mounting a comeback, and Alex Samuel put the tie to bed with a cool finish late on to earn Wycombe their first ever home win over Preston.
Non-League Chorley claimed an unlikely place in the fourth round as they proved too strong for a youthful Derby side in an extraordinary tie.
Connor Hall and Mike Calveley were the men on target as the National League North side claimed a 2-0 victory in what was theoretically an upset on a freezing afternoon in Lancashire.
Yet with the Championship visitors decimated by a Covid-19 outbreak at their club, the four division gap between the sides was wiped out, handing the initiative to the part-timers.
Derby, with interim manager Wayne Rooney and their entire first-team squad isolating, were forced to field a team made up from their youth sides in order to fulfil the fixture.
With an average age of just 19 and not a single game of first-team experience amongst them, it was an uphill struggle.
That the game went ahead was remarkable in itself. Quite apart from the coronavirus issue, sub-zero temperatures in Chorley over the past week had forced the sixth-tier side to rent covers to try to prevent their surface from freezing.
Their groundsman even camped at the ground in a tent to try to keep the pitch heated overnight.
League One high-flyers Doncaster caused an upset by defeating Championship side Blackburn 1-0 at Ewood Park.
Taylor Richards' third goal of the season three minutes before half-time - assisted in no small part by an Aynsley Pears howler - was enough to put Darren Moore's men into the draw for the fourth round.
Josh King netted his first two goals of the season as Bournemouth swatted aside League Two Oldham with a 4-1 victory at the Vitality Stadium.
Forward King has missed a large chunk of the campaign due to injuries and illnesses after failing to depart Championship Cherries in the summer transfer window.
But the Norwegian returned to his best with a classy brace for his first notches since July.
King also set-up Rodrigo Riquelme, after David Brooks and Dylan Bahamboula, from the penalty spot, exchanged first-half goals.
Sheffield Wednesday overcame both a coronavirus outbreak and a gallant Exeter to book their place in the fourth round with a 2-0 win at St James' Park.
The Owls had to shut their training ground this week due to a "significant number" of Covid-19 cases but they were still able to field a strong side against their Sky Bet League Two opponents.
Headers from Wayne Routledge and Viktor Gyokeres ensured Swansea comfortably made the fourth round with a 2-0 victory at Stevenage.
Goals early in each half ensured the Championship side were untroubled by their League Two hosts, although debutant Luke Norris missed a late penalty which could have set up an exciting finale.
Everton manager Carlo Ancelotti's gamble on resting key players almost backfired as a team registering eight changes laboured to a 2-1 extra-time win over Championship strugglers Rotherham.
The Italian left out top scorer Dominic Calvert-Lewin, Richarlison and goalkeeper Jordan Pickford, but their replacements were second-best for much of the 120 minutes at Goodison Park.
Rotherham, with just one win in their previous nine games, made six changes of their own but looked far more cohesive and they deserved more than just Matt Olosunde's maiden senior goal for their efforts.
Cenk Tosun's first strike for Everton since November 2019 was cancelled out just after half-time by the former Manchester United academy graduate, who won a solitary cap for the United States in 2018.
Substitute Abdoulaye Doucoure scored the eventual winner three minutes into the additional period but it was far from comfortable for Ancelotti's side, who progressed to the third round for only the second time in five seasons.
Lyle Taylor ended his longest goal drought since October 2017 to fire Nottingham Forest into the fourth round with a 1-0 win against Cardiff.
The former Charlton striker - one of eight changes made by home boss Chris Hughton following last weekend's win at Preston - took less than three minutes to claim the only goal of the game and his first in 13 outings.
Norwich scored two early goals to see off fellow Championship side Coventry 2-0 in a low-key third-round tie at Carrow Road.
An assured sixth-minute finish from Kenny McLean and a firm header from Jordan Hugill 80 seconds later settled a game that rarely hit the heights after an exciting start.
George Moncur scored the only goal of the game as Luton beat fellow Championship side Reading 1-0.
The midfielder volleyed the only goal of the third-round tie in the first half to decide the contest at Kenilworth Road.
Millwall avoided a potential banana skin at Meadow Park as they comfortably overcame Boreham Wood 2-0 to advance to the fourth round.