Tottenham boss Jose Mourinho says it is "completely impossible" for any more of his side's Premier League matches to be postponed.
Spurs’ trip to Aston Villa next Wednesday is under serious threat after nine first-team players tested positive for coronavirus this week at the English midlands club.
Another cancellation would follow last week’s postponement against Fulham after Scott Parker's side suffered a similar fate, while the reverse fixture with the Cottagers in April will also be moved after Spurs reached the Carabao Cup final.
Mourinho’s side are already facing a crippling fixture list in the second half of the campaign as they challenge on four fronts and the Portuguese has said he is not prepared to repeat the early season schedule where Spurs played seven matches in 22 days.
"I believe that it’s a completely impossible situation for a club to have three matches postponed, especially if that club plays in Europe," he said ahead of Sunday’s FA Cup trip to eighth-tier Marine.
"If it is a club that doesn’t play in Europe, there are always the UEFA fixtures, which are six to eight fixtures for Champions League teams and in the Europa League case even more.
"So for a Europa League team to have three matches postponed is impossible. Completely impossible. That’s the only thing I can say.
"The only thing we can say is what we did in the beginning of the season is impossible to repeat and we refuse to repeat. We have to defend our players, the integrity of our competition and we would never accept to play seven games in three weeks like we did before.
"Because of the moment of the season. One thing is beginning and another thing is mid-season. Also because of the difficulty and demands of the matches.
"One thing is to play, with all the risk like we did, the Europa League play-offs, and another is to play the Europa League knockouts with all the best teams.
"We cannot be put in an impossible situation. So I repeat: to have three matches postponed is impossible.
"It’s not for us to find decisions, I think it’s the moment for the Premier League to show leadership and make decisions.
"Decisions, where of course, for a club like us that is trying everything, every day to be ready to play, to follow the rules that we had in our hands since the beginning of the competition.
"We cannot be punished. If we don’t play against Aston Villa, we’ll have three matches postponed and that’s impossible because after the season we’ll have the Euros and the Euros will not be moved."
Mourinho confirmed that all of his squad and staff have tested negative for coronavirus in the latest round of testing.
Spurs played against Brentford earlier in the week and Bees manager Thomas Frank has since tested positive for the virus.