Republic of Ireland international Shane Long is a major doubt for Southampton's first game back against Norwich on Friday.
The striker, who sign during the enforced coronavirus break, has a a muscle problem. ed a new two-year contract
Winger Moussa Djenepo is the only Saints player certain to miss the trip to Carrow Road due to suspension.
The 22-year-old was sent off for a crude tackle on Isaac Hayden in their 1-0 home defeat to Newcastle in their final match before the coronavirus lockdown and begin a three-match ban.
Norwich have announced defensive trio Grant Hanley, Christoph Zimmermann and Sam Byram will miss the remainder of the Premier League season.
Hanley will undergo surgery on his hamstring this weekend, sidelining the club captain for 12-16 weeks, while Zimmermann (back and hamstring) and Byram (hamstring) also face long stints on the sidelines.
Marco Stiepermann will not be involved after the midfielder tested positive for coronavirus earlier this week.
However, he has returned two negative tests since then and returned to training on Thursday. Timm Klose will be available but is unlikely to start.