Newcastle United goalkeeper Martin Dubravka is set to be out for at least a month after tests confirmed medial knee ligament damage.
This will rule him out of Slovakia's Euro 2020 play-off against the Republic of Ireland in just over two weeks' time.
The keeper suffered the injury in the game against Southampton, playing the full match despite taking a knock in a collision with Danny Ings around the hour mark.
He went on to keep a ninth clean sheet of the season, but an assessment on Monday confirmed the damage.
He played all eight of Slovakia's Euro 2020 Group E qualifiers, as they finished third behind Wales and group winners Croatia.
He has an impressive run of consecutive Premier League appearances for his club, stretching back to his debut against Manchester United in February 2018.
Karl Darlow looks set to fill the void left by Dubravka, with Ireland international Rob Elliot, who hasn't played senior soccer since December 2017, likely to move up to the bench.