Manchester United will face Austrian side LASK in the last 16 of the Europa League following Friday's draw in Nyon.
Fellow Premier League side Wolves take on Olympiacos, while Rangers face Bundesliga outfit Bayer Leverkusen.
Rangers will be at Ibrox for the first leg on 12 March, with Wolves and Manchester United away from home. The second legs will take place on 19 March.
With no seedings or country protection, the draw could have pitted two of the British clubs against each other, but they were kept apart in what looks a favourable outcome.
However, United's little-known opponents LASK are currently top of the Austrian Bundesliga, while Olympiacos knocked out Arsenal with an extra-time winner at the Emirates on Thursday.
Rangers will be buoyed by their last-32 victory over Braga as they taken on Leverkusen, who are fifth in the Bundesliga, six points behind leaders Bayern Munich.
Elsewhere, Istanbul Basaksehir will take on Celtic's conquerors FC Copenhagen, Wolfsburg face 2009 winners Shakhtar Donetsk, Inter Milan are up against Getafe and Sevilla face Roma.
Eintracht Frankfurt, who drew 2-2 with Red Bull Salzburg on Friday to win 6-3 on aggregate, will play Swiss side Basel.
The Swiss government has banned all events involving more than 1,000 people until at least 15 March. The second leg is due be held on 19 March.
Europa League last-16 draw (first named team plays first leg at home)
Istanbul Basaksehir v Copenhagen
Olympiakos v Wolverhampton Wanderers
Rangers v Bayer Leverkusen
VfL Wolfsburg v Shakhtar Donetsk
Inter Milan v Getafe
Sevilla v AS Roma
Eintracht Frankfurt v Basel
LASK v Manchester United
