Shane Long has been ruled out of Southampton's FA Cup fourth-round tie against Tottenham with a knee injury.
The Republic of Ireland international picked up the knock during the midweek win over Crystal Palace at Selhurst Park and manager Ralph Hasenhuttl has a number of personnel changes to make.
Full-back Cedric Soares is expected to be out for around three weeks with knee ligament damage while centre-back Jannik Vestergaard (concussion) will also be sidelined.
The enforced absence of Portugal international Soares could see midfielder James Ward-Prowse deployed at right-back, with Kevin Danso another option.
Jan Bednarek is expected to be available after missing out against Palace with an Achilles issue, but fellow defender Yan Valery remains sidelined due to a viral infection.
Tottenham will be without Harry Winks for the trip to the south coast.
The midfielder picked up an ankle injury in the midweek win over Norwich and is set for several weeks on the sidelines.
Gedson Fernandes and Tanguy Ndombele will be hoping for starts at St Mary's Stadium, while Christian Eriksen's future is in the air as he closes in on a move to Inter Milan.
Harry Kane (hamstring), Moussa Sissoko (knee) and Ben Davies (ankle) continue their recovery.