Republic of Ireland's Shane Long scored his first goal in almost nine months but Southampton coughed up a two-goal lead in their 3-2 home defeat to Wolves.
Long claimed his first goal of the campaign in his 17th outing and his 35th minute header put the Saints into a commanding 2-0 lead at at the interval after Jan Bednarek opened the scoring at St Mary's Stadium.
The visitors however were a side transformed after the break and responded early in the second half as Pedro Neto scored from a drilled cross from Adama Traore.
Wolves were soon awarded a penalty after the video assistant referee (VAR) overturned on-field referee Darren England's initial decision not to give a foul on Jonny inside the box.
In-form Mexican striker Raul Jimenez scored from the spot before completing the comeback in the 76th minute with his 19th goal for Wolves across all competitions this season.
Southampton had their own chances to respond through Nathan Redmond and Ryan Bertrand but they failed to find the back of the net as the hosts suffered their first defeat in six league matches.
The result means Wolves moved up to sixth in the standings and level on points with fifth-placed Manchester United, while Southampton remain 12th.
Darren Randolph made his first West Ham start since returning for a second stint at the club, but the Hammers remain mired in relegation danger after they could only draw 1-1 with a rejuvenated Everton side at the London Stadium.
A scrappy first half low in quality burst into life just before halftime when Issa Diop headed in a Robert Snodgrass free kick to put the hosts in front.
But Everton's response was immediate and Lucas Digne's corner was flicked on by Mason Holgate and Dominic Calvert-Lewin headed in at the far post.
West Ham manager Davis Moyes, formerly the long-serving boss of Everton, has lifted the spirits since returning for a second stint in charge of the Hammers.
But his side did not offer enough to grab a precious winner in the second half as they remained only one point above the relegation zone. Carlo Ancelotti's Everton are 11th.
Pitchside monitors were used for the first time in the Premier League as Norwich City earned a crucial 1-0 win in their fight for survival over Bournemouth at Carrow Road, in a match where both sides had a man sent off.
Steve Cook's blatant handball in the penalty area as he attempted to block Ondrej Duda's strike earned the Bournemouth captain a red card with just 31 minutes on the clock.
Teemu Pukki dispatched the penalty down the middle, easing the home crowd's nerves.
Bournemouth pressed for an equaliser after the break and they got a boost as Ben Godfrey was sent off with 14 minutes left after referee Paul Tierney was advised by VAR to have another look at Godfrey's tackle on Callum Wilson.
After the Professional Game Match Officials Limited, the body that manages elite referees, issued guidance for referees to use the screens this week, Tierney took a second look and brandished the red card, having initially shown a yellow.
The home side held on nonetheless for the win, moving them to within three points of Bournemouth in 19th place, with Eddie Howe's men now three points from safety after a 10th defeat in their last 12 league games.
Jack Grealish scored a stunning second-half goal as Aston Villa rescued a point with a 1-1 draw against Brighton & Hove Albion in the Premier League.
Villa captain Grealish collected a pass from Douglas Luiz before firing a powerful left-footed strike from just inside the area with 15 minutes remaining at the Amex Stadium.
Both teams struggled to control the match in the opening stages before Leandro Trossard scored with Brighton's first attempt on target, seven minutes before halftime.
Moments after Grealish had blazed an effort wide for Villa, Brighton's Neal Maupay made a blistering run at the other end to set up Belgian winger Trossard, who fired a first-time shot past debutant goalkeeper Pepe Reina and into the bottom corner.
The result means Villa remain in the relegation zone with 22 points from 23 matches, while Brighton stay 14th.
