Alex Ferguson says a global Super League would not prove attractive to the leading English Premier League teams, adding that "clubs with great history could be lost" if the project was embarked upon.
The late autumn and winter months have seen much debate around the structure of the football calendar.
Various ideas have been floated, with FIFA expressing the desire to expand the Club World Cup to 24 teams by 2021, a plan which is resolutely opposed by UEFA.
Meanwhile, the European Clubs Association is pondering a restructure of the Champions League from 2024, discussions centring around the idea of a 32-team league in which each club plays 10 matches against 10 different opponents, with eight teams automatically qualifying for the knockout phase with a further 16 entering into a playoff phase for the right to join them.
And most controversially, the world governing body - at the insistence of Real Madrid President Florentino Perez - has recently been engaged in discussions around the possibility of a global Super League, in which it is envisaged that clubs would abandon their domestic league to take part.
The legendary former Manchester United manager has read about the proposals and can't see English clubs signing up.
"I struggle to see why an English team would need to leave," Ferguson told the BBC.
"Without question, it is money orientated, but surely this would not be attractive to our clubs in the Premier League, which at the moment is the best domestic league in world football and is well supported financially by Sky, BT and now Amazon.
"Furthermore, the attraction of playing in the Champions League is huge for players, coaches and fans alike, as it remains the ultimate test in club football.
"A lot of clubs with great history could be lost if their partners in the Premier League upped sticks.
"I strongly believe this is a realistic appraisal of the value of domestic football."
The leading player behind the scenes in the promulgation of the Super League idea is Real Madrid's Perez, who was appointed President of the new World Club Football Association when it was launched last month.
According to the New York Times, Perez has recently held talks with representatives of Europe's leading clubs, as well as FIFA President Gianni Infantino, around the possibility of developing a European wide league, one which over time would likely morph into a global league.
It is understood that the plans are not widespread and agreement between FIFA and the clubs is a long way off.
The idea has already met fierce opposition with UEFA President Aleksander Ceferin labelling it "insane", "selfish" and "egotistical" and arguing it would "clearly ruin football around the world."
