Cork City v Dundalk, Turner's Cross, 7:45pm
This fixture was earmarked at the start of the season as a potential blockbuster and could even decide the title race. While Dundalk kept their part of the bargain, the same can't be said for City who will be glad to bring their home campaign to the end.
The Lilywhites are a remarkable 49 points clear of their old rivals. Neale Fenn finally picked up his first win as City boss last week against UCD. Dundalk will be keen to respond to the end of their long unbeaten run away to Bohemians last week.
Cork City: City are boosted by the return of Ronan Hurley, Kevin O'Connor and Garry Buckley. Conor McCarthy picked up a quad injury in training on Wednesday and is a doubt.
Dundalk: John Mountney and Patrick McEleney return to the squad following their foot and hamstring injuries as does Patrick Hoban who comes back into contention following his suspension which means Vinny Perth has a full squad to choose from.
What they say
Neale Fenn (Cork City manager): "I sensed a little bit of a bounce this week in training, it's been really bright. It looks like a bit of a weight has been taken off the lads with the win (against UCD). There's a really good feeling around the squad this week.
"We're going into the game on Friday, it'll be difficult. Dundalk have the strongest squad, it'll be very difficult. The two teams were rivals up until this season, so they won't want to come here and be beaten."
St Patrick's Athletic v Bohemians, Richmond Park, 7:45pm - Live on RTÉ2
European football is within touching distance for Bohemians, with a point good enough to ensure their remarkable season is rewarded.
The Saints have stuttered somewhat under new boss Stephen O'Donnell but still remain in the hunt despite a mediocre season after good investment at the start of the year under Harry Kenny. They can move level on points with Derry City who have a difficult game in Sligo on Saturday.
St Patrick's Athletic: Stephen O'Donnell will be without the services of Republic of Ireland U21 international midfielder Jamie Lennon who serves a one match suspension.
Bohemians: to come
What they say
Stephen O'Donnell (St Patrick's Athletic manager): "It has been a long enough two weeks since the Waterford game... Bohs will be full of confidence having beaten Dundalk at home with a good performance, albeit Dundalk played a different system. It's going to be a tough game and there will be a great atmosphere."
"They will be very happy with their season to date as they’ve done really well so it is up for us to rise to the challenge and I’m sure our boys will. We have had two very good weeks of training and everyone is chomping at the bit and looking forward to it."
Keith Long (Bohemians manager): to come
UCD v Shamrock Rovers, UCD Bowl, 7:45pm
It has been on the cards for a while, but UCD will be relegated if they do not beat Shamrock Rovers tonight. The second part of the season has been difficult for the new Students and they will look to regroup when their fate is confirmed.
The Hoops are preparing for the FAI Cup final, with second spot already secured. Jack Byrne will not see action again this week due to suspension.
UCD: to come
Shamrock Rovers: Jack Byrne is suspended and Sean Callan will miss the rest of the season. Roberto Lopes returns from international duty.
What they say
Stephen Bradley (Shamrock Rovers): "I watched back UCD's game against Cork and they should have won. They did really well down there so it's not going to be an easy game for us. But we'll go and try and impose ourselves on them and win all three points. Neil Farrugia and Gary O'Neill speak very fondly of their time at UCD and really enjoyed their time there. It was a big part of their development. I'm sure it'll be strange for them going there and being in the opposition dressing room but I've no doubt that once the game kicks off their minds will be fully focused on winning it."
Finn Harps v Waterford, Finn Park, 8pm
Ollie Horgan's men are set to meet Cabinteely or Drogheda United play-off. The Finn Harps boss will be acutely aware that all that matters is getting into the right knick for those two crunch games.
Waterford have enjoyed a late resurgence in the league and will fancy their chance of catching Sligo Rovers in sixth spot.
Last week's defeat to Stenhousemuir in the Tunnocks Caramel Wafer Challenge Cup went under the radar, a disappointing 3-2 scoreline.
Finn Harps: Ollie Horgan has a full squad to choose from
Waterford FC: Cory Galvin and Georgie Poynton are sick but it's hoped they’ll make the squad. Zack Elbouzedi returned from international duty with a knock and will be assessed ahead of the game.
What they say
Finn Harps chairperson Sean Quinn: "We come to the last game of the regular season with the playoff position all but secured and getting that over the line will be a real achievement as 9th is our highest league finish in many years.
"It has been a tough battle since we kicked off back in February, but we hope Harps supporters will come out to help us get over the line and give ourselves a chance to secure a place in the top flight for next season".
Alan Reynolds (Waterford manager): "We have two games left and we want to win both. Away to Finn Harps is never easy especially when they're fighting for their lives so we need a good performance to have any chance of getting the points.
"They’ve beaten us this season already and Ollie always has them well prepared and Friday will be the same again. We have UCD next week in the final game so we’re pushing for six points to finish the season."
Follow St Patrick's Athletic v Bohemian FC (kick-off 7:45am) via the live blog on RTÉ.ie/Sport and the News Now App, or watch live on RTÉ2 and the RTÉ Player.