David McGoldrick and Callum Robinson have both returned to Sheffield United with shoulder and hamstring injuries respectively and will play no part in the Republic of Ireland's friendly against Bulgaria on Tuesday night.
McGoldrick earned his side a crucial point against Switzerland at the Aviva Stadium last night, heading home an 85th-minute leveller.
He returned to England for further treatment on a shoulder injury that he'd actually picked up before the Swiss game, while Robinson is also going back to the Blades to nurse a hamstring strain which forced him off before the hour mark.
Mick McCarthy said he will not be calling any more bodies into the panel to replace the pair.
"Both David and Callum won’t be coming back in when the squad report back to the Castleknock Hotel on Sunday," said the Ireland boss.
"David came into camp with a shoulder injury but was determined to play against Switzerland and what a game he had. He was brilliant from start to finish and capped off a great performance with a first Ireland goal that was no more than he deserved.
"Callum felt his hamstring in the second half of the game so it is best now that he also goes back to Sheffield United for treatment. There are a few other bumps and bruises about the place but we will see how everyone feels after their short break over the weekend and take it from there on Sunday."
McCarthy will be in Tallaght tonight to watch Stephen Kenny's Under-21s take on Armenia. He'll then take in Denmark's clash in Georgia on Sunday afternoon, a game that could have an enormous bearing on Ireland's Group D prospects.
"The Tbilisi game between Georgia and Denmark will tell us a lot," he said.
"We go to Georgia next so we'll be keeping a close eye on how that one goes. The group is tight and everything counts from here on in.
"I said after the game that it was like the Lansdowne Road of old on Thursday night and so many have agreed with that.
"The tone was set by the fans from the start and the place was rocking. They got behind us when Switzerland scored and then they took the roof off when David scored. It was very, very special so thank you to them all."