Bohemians v UCD, Dalymount Park, 7:45pm.
Bohs need to get back on form in the league having surrendered fourth place and are boosted by the dramatic nature of their FAI Cup win over Shelbourne.
The Students find themselves trailing Finn Harps by six points and with their relegation rivals at Oriel Park on Friday night, this could be an opportunity if they can get things right.
Bohemians: Skipper Derek Pender serves the final game of his four-match ban for the part he played in a post-match flare-up the last time these sides met.
Rob Cornwall (hamstring), Ryan Swan (hamstring) and Kevin Devaney (hip) are all available for selection once more, but James Finnerty (calf) is a doubt.
Long-term absentees Dinny Corcoran (ankle) and Cristian Magerusan (cruciate) remain out.
What they say
Andy Lyons (Bohemians player): "We're under no illusions going into any game that we have to be at it. We lost to them out in the Bowl and even when they came to Dalymount the last time they gave us a really good game in the first half.
"They’ve already beaten us so will feel confident again so we have to be at our very best."
Derry City v Shamrock Rovers, The Brandywell, 7:45pm
This should be a fascinating clash as City continue their push for a top three finish against the title-seeking Hoops.
It's a must-win for Stephen Bradley's men - as pretty much all games are due to the seven-point advantage Dundalk have opened up.
The Candystripes have really caught the eye are particularly potent at home.
Derry City: The home side have no major injury concerns ahead of the match although the Derry City manager Declan Devine said they would make a decision on Junior Ogedi-Uzokwe nearer to kick off.
Shamrock Rovers: The Hoops will be without Neil Farrugia, who is nearing a return to action. Leon Pohls is a doubt after he took a knock in training, as is Joey O’Brien has been playing the last few weeks with a bad ankle.
What they say
Declan Devine (Derry City manager): "We're pretty much looking at ten cup finals between now and the end of the season, and if we can replicate the atmosphere that we had here in the early games, then who knows what is possible" said Devine.
"This is a really tough match for us. Rovers have been building their team for a few years now and you can see how that experience is proving invaluable for them."
"They were very good in their European games; they play on the front foot and have really good options going forward."
"Despite that, I believe there has been very little between us in our meetings so far this season. Both teams like to get the ball down and play so this has the makings of a decent game for the fans."
Stephen Bradley (Shamrock Rovers manager): "Derry are having a very good season. Declan is doing a great job up there and he has got a good group of players together.
"It'll be a difficult game but we’re ready to go and win three points. The Brandywell is a pitch we enjoy playing on and it suits us."
Dundalk v Finn Harps, Oriel Park, 8pm
It's back to the bread and butter for Dundalk now they are out of Europe with the focus on securing that Champions League place again.
This is not the worst fixture to return with, although Harps are on their best run of the season and have an eye on eighth place Cork City.
But regardless, this will be a desperate quest to hold on for a point as Ollie Horgan admits.
Finn Harps: Ciaran Gallagher and young defender Michael Gallagher are injured. Keith Cowan is doubtful after missing the Shamrock Rovers game in Tallaght last Friday night.
What they say
VInny Perth (Dundalk head coach):
Ollie Horgan (Finn Harps manager): "Our lads are realistic to know that it is going to take some performance from us and a lot of luck to even get a point against a side that is very well placed to win the Premier Division again.
"Dundalk are a full-time professional outfit and are able to rotate the squad and freshen things up when it needs to be done. We don't have the same luxuries but we’re not complaining. Our lads would rather be going to Oriel Park tomorrow night than playing anywhere in the First Division."
St Patrick's Athletic v Sligo Rovers, Richmond Park, 7:45pm
Liam Buckley returns to his long-time home of Richmond Park for the second time this season. Sligo have been mixed to say the least and need another couple of results to stave off the sides at the foot of the table.
The Saints continue their chase for Europe and sit just six points off that spot going into this game. With Derry facing Shamrock Rovers, it could be a chance to close that gap.
St Patrick's Athletic: The home side will be without the services of trio Mikey Drennan, Ciarán Kelly and Conor Clifford through suspension, while Chris Forrester is a doubt through illness. The Saints' manager however is boosted by the return to fitness of Kevin Toner and Gary Shaw.
Sligo Rovers: Ronan Coughlan returns from suspension while Niall Morahan remains out with a knee injury. Morahan is set to be the only absentee from the Rovers squad.
What they say
Harry Kenny (St Patrick's Athletic manager): "We are coming into the game off two good wins lately. Last week was a tough game but we slugged it out and got the win. I was happy with the chances we created but we need to look to take more of the chances we create.
"We have had some good games with Sligo already this season and we have done well against them. Each game though has been tough and we have had to work hard so the lads know we will have to be in good form on Friday to pick up the points."
Liam Buckley (Sligo Rovers manager): "It was nice to score some goals last week and it always does give you that lift.
"We'd like to carry that into Friday. I know most of the St Pat’s squad from my time there, they’ve done well and have added some new players too recently.
"But I’m just concerned with ourselves and getting ourselves up to speed and to a level.
"It would be good to get the result on Friday night so we can keep in that mix in that part of the table."
Waterford v Cork City, RSC, 7:45pm
Few could have predicted that this game would be about trying to open up a gap from the relegation zone at the start of the season. There has been little to smile about for both sides but a win would be a big help to getting away from that scene.
Cork needed penatlies to overcome Cabinteely in the FAI Cup and will look to build on that positive outcome that for so looked like being disastrous
Waterford: Sam Bone made his return from injury last Sunday and has had no ill effects since. Zack Elbouzedi and Will Fitzgerald missed last weekend's FAI Cup and continue their recovery from injury; both are expected to miss the game.
Cork City: Mark O'Sullivan is likely to be back in contention while Conor McCarthy is being assessed after being taken off in the game against Cabinteely. Cian Murphy and Cian Bargary are both still sidelined.
What they say
Alan Reynolds (Waterford manager): "It's been a busy spell for us with a run of away games since our last home match at the RSC, so it’ll be good to get back there this weekend.
"John will have Cork well prepared and we know they'll be up for the game; Munster Derby games are always a highlight of the season and we want to win it."
John Cotter (Cork City manager): "It's massive for both clubs. No matter what side you go down with, or what side they have at the time, it's never an easy place to go.
"The crowd down there is always passionate, and we always get a good following down there as well. It's something you have to look forward to. Hopefully after last week, the boys have gotten a bit of confidence and can take it into Friday and come away with a positive result."