Shamrock Rovers (2) v SK Brann (2), Tallaght Stadium, 8pm
The Hoops plundered a really good 2-2 draw in Norway last week thanks to Roberto Lopes's last-gasp leveller.
That result sets them up for a humdinger in Tallaghgt. It's seven years since Shamrock Rovers made it to ehe group stages of the Europa League. They'll need a huge display on their own patch to keep alive dreams of emulating those memorable feats.
Shamrock Rovers: Aaron McEneff has trained all week without any issues having made his return to action off the bench against Brann last week. Neil Farrugia remains out for the hosts only injury, but apart from that, Stephen Bradley has no concerns.
Stephen Bradley (Shamrock Rovers): "It doesn’t matter to us if people look at us as favourites now. What we have to understand is that we’re playing a very good side. It’s going to be a difficult game but I said before the first leg it’s a tie that we fully believe we can win and nothing changes that.
"We still have to go and win this game. There’s no other way of approaching it and they’ll obviously think the same. You can’t sit in against a team like this. If you do that you’re asking for trouble and you’re going to get punished."
Progres Niederkorn (2) v Cork City (0), Stade Municipal de Differdange, 6.30pm
The Leesiders face an enormous task in Luxembourg after a disappointing result at Turner's Cross last week.
Progres scored twice in the first half in Cork to put themselves in a pole position to set up a second qualifying round clash with, most likely, Rangers.
Cork aren't throwing in the towel but going to have to find a huge display from somewhere to pull this one off.
Cork City: Shane Griffin and Kevin O'Connor could both make it, but Cian Murphy and Cian Bargary are definitely ruled out.
John Cotter (Cork City): "Obviously, we gave away two soft goals (last week), but we have discussed it and had some good training sessions, so we have to be positive going over there. That’s the way we have approached it this week and we will look to bring that into the game.
"We have to go out and try to get the first goal, and see where that takes us, so that’s what we will be planning to do. If we can get the first goal, it will open up the tie and I feel we can do that if we perform like we should perform."
IFK Norrkoping (2) v St Pat's (0), Oestgoetaporten, 7pm
St Patrick's Athletic are also massively up against it as they travel to Sweden looking to overtun a two-goal deficit.
Simon Thern and an own goal from Lee Desmond did the damage in Inchicore, but Harry Kenny’s side travel to Norrkoping in good spirits with a full and healthy squad to select from.
St Pat's: The Saints have no injury concerns for the second leg.
Harry Kenny (St Pat's): "It’s a tough ask, but there's no point in being in the tie if you are not going to go for it so we’ll get our plans done. I thought we acquitted ourselves quite well in the first leg, but just gave away two sloppy goals. And football is funny like that when you look at Spurs and Liverpool last season turning around their European semi-final deficits in cup football.
"If we get a goal early on at any stage, or even into the second half, it puts the frighteners on them a little bit and you never know what could happen. The whole stadium and the opposition can get nervy and can go quiet so we’ll be trying to get the first goal and take it from there."