Bohemians v Shamrock Rovers, Dalymount Park, 8pm
"It's happened again, Shamrock Rovers, it's happened again" - the words of Bohemians fans after the latest derby win for the north Dublin outfit in Tallaght in May.
Dundalk opened up a five-point lead last weekend when the Hoops dropped points against Derry, so even if this wasn't a fixture against their arch-rivals, it would be a massive game for Stephen Bradley's men.
A victory would give the Hoops a enormous lift and break down a mental barrier that could signal another fantastic run of form like seen earlier in the season.
Bohs needed their 5-3 win over Finn Harps to stop the rot after four defeats in five matches. This is a big ask, especially when many players absent.
But they haven't lost to their arch-rivals in seven consecutive league meetings, six of which they win.
Dinny Corcoran (broken ankle), Danny Grant (hamstring) and Rob Cornwall (Achilles tendon) are all injured. Darragh Leahy is away on Ireland U21 duty while Derek Pender and James Finnerty are suspended.
Aaron McEneff and Sam Bone are still out but Sean Kavanagh returns.
Keith Long (Bohemians, speaking to The Irish Sun): "We’ll have, for want of a better word, a makeshift back four.
"But it’s an opportunity for other players to come in and hopefully do well.
"It will be some boys’ first taste of the derby against Rovers and some games take on a life of their own."
Stephen Bradley (Shamrock Rovers): "If we play like we did against Derry you win 99% of your games. We were very good but sometimes these things happen. Bohs is a big game and one that we’re looking forward to.
"Derbies are always different games but we’ll go there with a game plan to go and win the game. So tomorrow we just need to perform like we have been this season. We’ve sold out our allocation so it’ll be a good crowd. Our fans have been great all year."
St Patrick's Athletic v Finn Harps, Richmond Park, 7.45pm
St Patrick's Athletic continue to pick up points in the chase for a European place. With a record of seven wins, draws and defeats in their 21 games to leave, fans are concerned but still waiting for Harry Kenny's men to kick on.
This game, couple with UCD after the break, is a huge opportunity to close the gap on Derry City and a must-win.
Harps, after their mini-revival, have conceded 17 goals in their last four games - all ending in defeat. They aim to repeat their draw from early in the season in Richmond Park.
St Patrick's Athletic
Harry Kenny will be without midfielder Jamie Lennon, who remains on Republic of Ireland U-21 duty at the Toulon Tournament, while Dave Webster misses out through suspension. The Saints are boosted however by the return of both defender Lee Desmond and midfielder Conor Clifford from injury.
Ollie Horgan has to plan without the suspended Mark Coyle while John Kavanagh, Michael Gallagher, Harry Ascroft and Ciaran Gallagher remain out through injury. However, Caolan McAleer and Sean Boyd return to the squad following respective one-match bans.
Harry Kenny (St Patrick's Athletic): "Harps will give us a real test as they are starting to pick up a few more results lately as they settle into the division. We had a tough game against them in Inchicore earlier in the season and we expect another difficult game this Friday. We played well last week against and created a lot of chances so hopefully this week we can do the same and convert a few."
Ollie Horgan (Finn Harps): "We can’t go back and change what has happened over the last four games, but we have a chance now to turn things around against Pat’s tomorrow night. That won’t be easy but the lads have to step and try it make it happen. We did draw up there in the early stages of the season and it would be great to repeat that result."
Sligo Rovers v Cork City, the Showgrounds, 7.45pm
John Cotter is auditioning for the permanent role at Turner's Cross, and while his bosses will worry about overcoming the lack of a completed Pro Licence, he will focus on achieving the results that merit the appointment.
City sit 11 points off a guaranteed European position and Sligo are one of four sides in their way.
The Bit O' Red have an ambition to try to sneak into the top four - which could be good enough for Europe if a top three side win the FAI Cup - but the likilhood it's too early in the Liam Buckley era to achieve it.
However, a victory here would close the gap to fourth to just three points. All to play for in The Showgrounds.
Kyle Callan-McFadden is suspended but John Mahon returns. Regan Donelon and Johnny Dunleavy are injury doubts and will be tested pre-game. Dante Leverock will play the first game for Bermuda in the Gold Cup on Sunday against Haiti so misses out.
Cian Murphy, Shane Griffin and Pierce Phillips are all out while Seán McLoughlin and Conor McCormack are injured.
Liam Buckley (Sligo Rovers): "These are games where it’s hard and you have to fight and dig in. Outworking your opponent is key to coming out on top and both teams will know that. That’s the basic for any match in this division.
"We put in a good shift last week and while it was disappointing not to come away the win, the endeavour was good and we’ll look for that again.
"We feel we are capable of improving on the game earlier in the year (against Cork) and have the players in our ranks to create something and take the chances to come away with a win."
John Cotter (Cork City): "Sligo is always tough, but we've had a decent record away from home this year. Whether you're in Turner's Cross or away from home, the main thing is that you do your work and that you're prepared for it.
"The last couple of weeks have given us a chance to do that, so hopefully on Friday we can put in a performance, play well and come away with a result."