Tottenham defender Jan Vertonghen will be fit to play Ajax in the Champions League semi-final second leg after recovering from a head injury.
Erik Lamela (hamstring) could be involved after a lengthy absence while Son Heung-min is available following his suspension for last week's first leg.
Harry Kane (ankle), Davinson Sanchez (thigh) and Harry Winks (groin) are all injured, along with Serge Aurier (hamstring).
Meanwhile, Mauricio Pochettino has said that if Tottenham were to win to Champions League this season, he would consider "maybe doing something different in the future".
Spurs trail Ajax 1-0 from the first leg of their semi-final.
Speaking ahead of the return leg in Amsterdam, Pochettino said: "To win the Champions League with Tottenham in these circumstances this season, maybe I need to think about maybe doing something different in the future."