Republic of Ireland boss Mick McCarthy was handed a couple of concerns on Saturday after Shane Long limped out of Southampton's clash with Tottenham while Seamus Coleman pulled out of the Everton team due to illness.
Ireland kick off their Euro 2020 qualification campaign against Gibraltar in a fortnight.
McCarthy named Long and Coleman in his extended squad on Wednesday and both men will likely play key roles in the mission to get out of Group D.
Long was taken off for Stuart Armstrong in the 73rd minute at St Mary's Stadium, a substitution that actually proved a turning point as the Saints scored twice, through Yan Valery and James Ward Prowse, to cancel out Harry Kane's opener and bag a shock win.
The Tipperary attacker had started on the bench himself, coming on for Oriol Romeu at half-time and had caught the eye, causing Spurs problems with a typically high-energy and robust display.
Coleman had been named to start at right-back for the Toffees, who threw away a two-goal lead in a 3-2 loss at Newcastle.
He took part in the warm-up but did not feel up to starting and was replaced in the line-up by Jonjoe Kenny.
McCarthy will be more worried by Long's withdrawal and will anxiously await an update on the extent of the problem from Southampton.
Michael Obafemi has been ruled out for the season with a hamstring injury, while Preston's Callum Robinson hasn't played since November, after he also badly damaged his hamstring.
McCarthy has been keen to bolster his striking options and has opened dialogue with Leeds frontman Patrick Bamford about declaring for Ireland. Hull's Will Keane, who represented England at underage level, has already begun the international transfer process.