Italian Serie A club AS Roma said they had parted company with coach Eusebio Di Francesco this afternoon, one day after being knocked out of the Champions League by Porto.
"Di Francesco has left the club with immediate effect," the club said in a statement.
"The club would like to thank Eusebio for his work during his time at AS Roma and wish him success in the future."
The Italians took a 2-1 lead to Portugal, but they were beaten after extra-time. Alex Telles's late penalty, awarded using VAR, was enough to see Porto through.
Di Francesco was in his second season at the club, having led them to third place in Serie A last term. He also brought them to the semi-finals of the Champions League after a memorable win over Barcelona, in which they overturned a three-goal first-leg deficit.
Italian media reported that Claudio Ranieri, fired by English Premier League side Fulham last week, was a possible replacement.