Cork City v Derry City, Turner's Cross, 7.45pm
Cork sleep-walked out of the traps, losing to St Pat's and then Waterford, but talk of their demise may be greatly exaggerated.
John Caulfield's side are nothing if not resilient, and their 2-1 win at Sligo Rovers on Monday could prove a turning point.
Derry City have two wins from three and bounce down to Turner's Cross off the back of a thrilling 3-2 win against Waterford.
The Candystripes have a poor record at the Cross but travel in decent form. They'll be looking to ask more questions of last year's runners-up.
Cork City: Alan Bennett and Matthew Gillam are both definitely out. Gearóid Morrissey, Graham Cummins and Karl Sheppard have all had knocks and will be assessed ahead of the game.
Derry City: With everyone else fit, Conor McDermott and Gianni Seraf have been added to the squad.
John Caulfield (Cork City): "Derry had a great win in the Brandywell against Waterford, so we’re under no illusions. We have to be at our best again and play well. It’ll be a tough game, but it’s always a good fixture to have. Whether it’s home or away, it’s always a fixture to look forward to."
Declan Devine (Derry City): "Cork is the most difficult venue," he told the Derry Journal. "There, Dundalk and Shamrock Rovers are the three most difficult venues in this country to get a result from. But we'll go down there and have a go. We always knew the first three or four games were going to be extremely difficult."
UCD v St Patrick's Athletic, UCD Bowl, 7.45pm
It's been a chastening return to the top flight for Collie O'Neill's Students who have lost all three games they've played.
They looked like they were going to pull off an almighty shock at Oriel Park on Monday when Neil Farrugia blasted them in front but Pat Hoban and Michael Duffy turned it around for the hosts in the second half.
St Pat's are yet to taste defeat with two victories and a draw to their name. Harry Kenny's men have been dogged if unspectacular so far but there's no denying the quality they have in the ranks, and they'll fancy themselves to pick up another three points on the road.
UCD: To come
St Pat's: The Saints remain without the services of Dean Clarke through injury while captain Ian Bermingham faces a late fitness test.
Collie O'Neill (UCD): To come
Harry Kenny (St Pat's): We had a difficult game last Monday against Finn Harps who are a newly promoted side. We now face UCD on Friday, another promoted side, so we know it will be another tough game. We know that UCD are a talented team and are settling to the Division. They ran Dundalk really close on Monday and will be fired up to get their first points against us
Waterford v Bohemians, the RSC, 7.45pm
League leaders Bohemians travel to Waterford, hoping to extend their 100% start to the season, having claimed bragging rights in the Dublin derby on Monday after beating Shamrock Rovers.
Waterford have picked up three points in the opening three matches after a narrow defeat on Monday night. The long trip to face Derry City saw the Blues battle back from behind and push for an equaliser but ended in a 3-2 defeat.
That result followed the 2-0 win against Cork City last Friday, and a narrow 2-1 defeat against Shamrock Rovers two weeks ago.
Waterford: Kevin Lynch is a doubt after coming off early in Derry on Monday.
Bohs: Michael Barker (hamstring), Promise Omochere (ankle) and Cristian Magerusan (cruciate) remain out. Kevin Devaney (knee) remains a doubt.
Alan Reynolds (Waterford): "It’s been a busy start to the season and it’s important to remember that it’s early days still, too. We’re very much a new team from last season and it’s going to take time for everybody to settle in, get used to each other and get more used to playing with each other.
"We’ve had massive crowds in the RSC in the first game and again in Turners Cross and more in Derry on Monday, so we know we’ll have another noisy RSC to push us forward and we’re all looking forward to it."
Paddy Kirk (Bohs defender): "We've done our homework on them as we do all teams. We're going down in good form with three wins and three clean sheets. But they are a very good side."We've done well at the back so we want to continue to be solid there and build on that.
"All the lads who have come in have settled in so far and James Talbot has done very well since coming in as goalkeeper. He's been like a young Supps (Shane Supple). Maybe it's the GAA background... except he's a bit mad!
Finn Harps v Sligo Rovers, Finn Park, 8pm
Sligo Rovers take on Finn Harps on Friday night as the Bit O’ Red travel to Finn Park for an eagerly awaited encounter.
Rovers have one point from the first three matches but have shown positives signs throughout.
Injuries have been a hindrance early in the season and there is mixed news ahead of this game.
Finn Harps: Harry Ascroft and Mark Timlin remain on the injury list, while Sam Todd is a doubt.
Sligo Rovers: Regan Donelon is out with a hamstring problem while Johnny Dunleavy (groin) and Ronan Coughlan (hamstring) will have late fitness tests. Ronan Murray (ankle) returned to training on Thursday and could link up with the squad for the first time.
Ollie Horgan (Finn harps): "Sligo might only have a point on the board but they will feel hard done by because they only lost to St Pat’s when Mikey Drennan got a very late goal at the Showgrounds last Friday night. Liam Buckley is building a new side but he’ll be pushing for a place well up the table come the business end of the season."
Liam Buckley (Sligo Rovers): "I think you can expect a hard game anywhere you go in this league. It’s a real scrap in every match. Finn Harps will not be easier than Pat’s or Cork, and I think that has already been shown. What I want from us is to be better in creating opportunities and remember just how much you need to dig in."
Shamrock Rovers v Dundalk, Tallaght Stadium, 8pm
The most eye-catching fixture of the night and, even at this juncture of the season, a massive one for both sides. Shamrock Rovers suffered yet more Dublin derby pain on Monday night when Bohs made the most of their man advantage, after Aaron Greene saw red, to snatch a 1-0 win.
The Hoops had won their first two games before the Dalymount setback but they have a golden chance to reassert their title credentials. It's been a bit patchy from the Lilywhites thus far. Draws against Sligo Rovers and Finn Harps were followed by a narrow win against UCD at Oriel Park. The champions will want to make a statement in Dublin, not to mention avoid losing any more ground on the early pace-setters.
Shamrock Rovers: Ethan Boyle is out. Dylan Watts carried a knock into the Bohs game then and got a bang on the same area but Bradley expects him to be okay. Aaron Greene is suspended after seeing red at Dalymount Park. Orhan Vojic [rib] remains a doubt.
Dundalk: Jamie McGrath made his return from a groin problem on Monday evening against UCD and is available once again. Robbie Benson (leg) and Patrick McEleney (foot) are out. Sean Murray is doubtful after picking up an injury against the Students.
Stephen Bradley (Shamrock Rovers): "We know they’re a good side. Their team hasn’t changed and they’re still the ones to beat and we’ve got a chance to do that. We were disappointed on Monday but we moved on. It’s gone and we’ve prepared for Dundalk all week. It’s a game we’re looking forward to and one I believe we’re ready for. The last three games have shown we’re ready for it."
John Gill (Dundalk): "It’s a massive game but it’s not going to define either of our seasons. It’s only four games in and there is a lot to play for. Our players enjoy going to Tallaght. They have always played well there. We go into the game now with confidence and we go there looking to get a positive result."