Lionel Messi became the first player to score 400 LaLiga goals as leaders Barcelona claimed a comfortable 3-0 victory over Eibar at the Nou Camp.
Luis Suarez also struck twice as Barca maintained a five-point advantage over Atletico Madrid at the top of the table.
Messi's remarkable landmark strike extended his own LaLiga record - Cristiano Ronaldo is the only other player to have scored more than 300 goals in the Spanish top flight - and came in just his 435th appearance in the competition.
Philippe Coutinho was at the heart of the opener, playing a one-two with Suarez and then sliding the Uruguayan in on goal with a defence-splitting pass.
Suarez needed a couple of touches to get the ball out from under his feet but he quickly adjusted to shoot beyond the advancing Asier Riesgo.
Messi's milestone strike came moments after he appeared to be struggling. The Argentinian seemed to be holding the top of his leg early in the second half but he soon shrugged off any problem as he struck after 53 minutes.
Suarez and Coutinho were again involved as the defence was opened up before Messi finished with a powerful left-foot drive.
The third goal duly came just before the hour as Suarez raced through from and flicked past Riesgo with the outside of the boot.
Second-placed Atletico kept up the pressure on Barca with a controversial 1-0 home win over Levante.
Antoine Griezmann scored from the spot but the penalty - awarded by the Video Assistant Referee for a handball by Nikola Vukcevic - left Levante far from happy.
Real Madrid moved up to fourth after edging past Real Betis 2-1 at Estadio Benito Villamarin.
Ballon d'Or winner Luka Modric opened the scoring for Madrid with a left-footed effort after 13 minutes.
Betis refused to lie down and equalised after 67 minutes through former Madrid midfielder Sergio Canales.
Santiago Solari's side had the final say with Dani Ceballos - who was a 2017 signing from Betis - scoring in the 88th minute to leave Madrid 10 points behind Barca.
Elsewhere, Inaki Williams struck in either half as improving Athletic Bilbao beat third-placed Sevilla 2-0 at San Mames.