Ralph Hasenhuttl started his reign as Southampton manager with a 1-0 defeat at Cardiff, which leaves his new side second bottom.
Cardiff, who climb to 14th, broke the deadlock on 74 minutes after Callum Paterson robbed Saints defender Jannik Vestergaard on the edge of the box.
West Ham came from behind to beat Crystal Palace 3-2 at the London Stadium.
James McArthur put the Eagles in front on six minutes after the home defence failed to deal with a free-kick.
The Irons were level three minutes into the second half when Scotland midfielder Robert Snodgrass curled in a 20-yard effort.
Javier Hernandez put West Ham ahead when the Mexico forward turned the ball home from close range on 62 minutes after Wayne Hennessey parried Felipe Anderson's free-kick.
Before Palace could regroup, they were 3-1 down on 65 minutes as Brazilian Anderson clipped the ball into the top corner.
Substitute Jeffrey Schlupp's header gave the Eagles hope with 15 minutes left, but there was to be no dramatic finale.
Burnley moved out of the bottom three with a 1-0 home win over Brighton.
Defender James Tarkowski deflected in a shot from Jack Cork to give the Clarets the lead five minutes before half-time, which proved enough for maximum points.