La Liga leaders Barcelona fell to a first home defeat in any competition for more than two years when they were beaten 4-3 by Real Betis at the Nou Camp on Sunday despite Lionel Messi returning from injury.
Ivan Rakitic was sent off for the Catalans in a calamitous defensive showing.
Betis's livewire winger Junior gave the visitors a deserved lead in the 20th minute, finishing off a hugely impressive counter-attack that had started in their own penalty area, while captain Joaquin doubled their lead in the 35th after another venture down the wing from Junior.
Messi pulled Barca back into the game by converting a penalty midway through the second half but Betis restored their two-goal cushion through Giovani Lo Celso.
Arturo Vidal quickly responded with a goal down the other end but Rakitic was then dismissed for a second booking and Sergio Canales soon made it 4-2.
Messi scored from close range in stoppage time but Betis hung on to clinch a first league win at the Nou Camp since 1998.
