Glenn Murray's 100th goal for Chris Hugton’s Brighton & Hove Albion boosted the Seagulls to a third straight Premier League win as Wolves went down 1-0 on the south coast.
Republic of Ireland defender Shane Duffy had fired Nuno Espirito Santo's ambitious side a warning in the first half when heading against a post but it was veteran forward Murray who settled the match in Brighton's favour by following up Bruno's miss, minutes into the second half.
Callum Wilson heaped more woe on struggling Fulham with a double at Craven Cottage as Bournemouth ran out 3-0 winners.
The Cherries striker converted an early penalty after being brought down by Timothy Fosu-Mensah and, after David Brooks made it 2-0 by shooting through Sergio Rico's legs in the 72nd minute, Fulham lost Kevin McDonald to a red card.
A fantastic through ball from Ryan Fraser allowed Wilson to beat the goalkeeper at the near post, sealing a convincing win.
Roberto Pereyra scored a fine solo goal to kick-start Watford's dominant 3-0 home victory over Huddersfield, who sank to the bottom of the table.
The former Juventus winger dribbled past the entire Terriers defence at Vicarage Road to open the scoring after 10 minutes, not long before Gerard Deulofeu steered a fine finish across Jonas Lossl to double the hosts' lead.
Isaac Success was well-placed to bundle the ball over the line after Watford produced a clever free-kick routine late on.
Elsewhere, Southampton and Newcastle's toothless runs continued with a dire goalless draw between the clubs at St Mary's.
Saints midfielder Mario Lemina enjoyed the best opportunity, striking a post with a flicked effort in the first half.
Sadio Mane scored twice and Mohamed Salah provided two assists as Liverpool took over at the top of the Premier League table by beating Cardiff 4-1 at Anfield.
