Israel 3-1 Republic of Ireland
Substitute Ronan Hale's second-half strike was not enough as the Republic of Ireland's hopes of reaching the 2019 European Under-21s Championship finals ended in Israel.
Noel King's men went into their penultimate Group 5 qualifier in Akko needing a victory ahead of their trip to face leaders Germany on Tuesday.
But they were beaten by Israel despite Derry City's Hale dragging them back into the game with a well-taken 64th-minute equaliser five minutes after replacing debutant Jordan Shipley.
Midfielder Gavriel Kanichowsky had fired the home side into a 15th-minute leader after Neta Lavi's cross had only been half-cleared in a difficult first half for the visitors.
However, they responded and were back in it with 26 minutes remaining when Hale latched on to a poor clearance and finished emphatically to give Ireland hope.
But the Republic were dealt a further blow with 13 minutes remaining when Maxim Plakushchenko's cross eluded everyone and dropped in.
King made a double substitution with time running down, sending on attacking players Jamie McGrath and Jake Mulraney, but the Republic were caught on the counter deep into added time as Yonatan Cohen wrapped up victory.