Former Republic of Ireland frontman Daryl Murphy set Nottingham Forest on their way to a Carabao Cup second-round defeat of his former Newcastle United.
Murphy, who retired from international duty back in January, steered home a second-minute header and that looked to have won the tie.
As the contest entered six minutes of stoppage time, Salomon Rondon's first goal for the Magpies seemingly secured the visitors a penalty shoot-out until Matty Cash and then Gil Dias gave Forest a dramatic 3-1 victory.
The Premier League side were convinced they should have been awarded a penalty at 2-1 for keeper Luke Steele's challenge on Ayoze Perez.
Rafael Benitez made seven changes to the side which lost 2-1 to Chelsea on Sunday as he tried to protect his big guns after suggesting the club's summer transfer business had left his squad short, but saw his team slip to a third defeat in four matches with champions Manchester City waiting in the wings on Saturday.
Another Irish striker, Aiden O'Brien, was Millwall's hero as his side came from behind twice to beat League One Plymouth 3-2.
O'Brien won it from 35 yards with a minute of a pulsating tie remaining after the visitors had led 1-0 and 2-1.
Jamie Ness headed Argyle into the lead four minutes before the break, but then conceded a 64th-minute penalty from which Shaun Williams equalised.
However, they were level for just three minutes when Freddie Lapado fired Plymouth back ahead, only for another substitute, Lee Gregory, to head the Lions back into it seven minutes from time and pave the way for O'Brien's heroics.
There was no such drama for Everton as Dominic Calvert-Lewin struck twice after Gylfi Sigurdsson had opened the scoring to seal a 3-1 victory over Championship Rotherham.
A Toffees line-up featuring eight changes from the weekend took a 28th-minute lead courtesy of Sigurdsson's close-range finish and Calvert-Lewin doubled the dose 16 minutes after the restart.
Will Vaulks pulled one back for the Millers with four minutes remaining, but Calvert-Lewin doubled his tally within seconds to win the tie.
Watford boss Javi Gracia rested his entire starting XI from Sunday's 2-1 Premier League win over Crystal Palace, but still saw his team ease past Championship Reading 2-0.
Nathaniel Chalobah and Marco Navarro had already threatened for the visitors when Isaac Success opened the scoring from close range eight minutes before the break, his first goal since October 2016.
Debutant Domingos Quina extended the visitors' lead in spectacular fashion 17 minutes into the second half and that proved enough to maintain the Hornets' 100% start to the season.
