Bohemian FC v Cork City, Dalymont Park, 7.45pm
Cork City have looked like champions elect from way out, but John Caulfield's men will hope to finally put their drawn-out procession to bed at Dalymount with the win that would make certain of it.
Dundalk spoiled the party at Turner's Cross with a late leveller two weeks ago but even if they beat Bray tonight, the Leesiders will take the crown with three points.
Keith Long's men are safe in mid-table, though their fans will expect a strong showing in their second last home game of the campaign.
Bohs: Lorcan Fitzgerald (knee) and Warren O'Hora, who aggravated a hamstring problem while on international duty with the Ireland U19s, are out. Keith Ward (ban) misses out but Paddy Kavanagh return from suspension. Eoin Wearen (cruciate) remains sidelined.
Cork City: Steven Beattie is suspended, while the visitors are without long-term absentees Johnny Dunleavy and Alec Byrne. Conor McCormack picked up a knock in training during the week and will be assessed ahead of the game.
Keith Long (Bohs): "It's a great game to be involved in. There's a lot of expectation on Cork City. But we've shown we can beat them already this season - we were the first team to do so. We will have to be at our very best again but we've nothing to fear from them."
John Caulfield (Cork City): "Nothing comes easy, but we are in the driving seat. The most important thing for us, after going through a shaky spell, was to get back to what we are good at and the last couple of performances have shown that. We are happy that we are back to that and hopefully it’s good for the run-in."
Dundalk v Bray Wanderers, Oriel Park, 7.45pm
Dundalk's reign as champions is almost certainly over but they can take several positives out of the season, with the EA Sports Cup in the cabinet, and an FAI Cup final at the Aviva Stadium to look forward to, so they will want to keep their foot on the throttle.
It's been a hugely difficult campaign for Bray but the Wicklow side will still be targeting a top-five finish in the league campaign sitting three points clear of sixth-placed Bohemians with three games to play.
Dundalk: Steven Kinsella, John Mountney and Dane Massey all miss out through injury, as do Niclas Vemmelund and Patrick McEleney. Tommy Stewart and Chris Shields are doubts. Conor Clifford is serving a six-month ban for betting offences.
Bray Wanderers: To follow
David McMillan (Dundalk): "We have three league games remaining and we didn’t want those games to peter out, we wanted something at the end of it. Everyone will be vying for a place come the Aviva so it should keep us nice and competitive for the last few league games."
Galway United v St Pat's, Eamonn Deacy Park, 7.45pm
It's an absolutely titanic tussle out west as third-from-bottom Galway host St Pat's, a point ahead of them.
Both clubs played out dramatic draws last week. The Saints conceded an injury time equaliser against Limerick while Galway drew 3-3 at Bray Wanderers, with Ronan Murray missing a 92nd-minute penalty to win it.
When the sides met in April and June, both league games finished 1-1. However Shane Keegan's side knocked Pat's out of the FAI Cup at the end of August, coming away from Richmond Park with a 2-0 win.
Galway United: Shane Keegan has a fully fit squad to choose from.
St Pat's: The Saints remain without the injured Darren Dennehy, while goalkeeper Barry Murphy is pushing for a place in the matchday squad having returned to full training.
Shane Keegan (Galway United): "The prize on offer is massive in this game. If either team wins, they would be placed in a very strong position to confirm their Premier Division safety. It's a huge motivator for both sides. When we played Sligo at Eamonn Deacy Park, we had a big crowd in and there is absolutely no doubt that it makes a big difference. It makes a world of a difference to the players, the atmosphere was electric."
Liam Buckley (St Pat's): "We’ve played each other three times this season to date and it’s been very close on each occasion. Shane Keegan encourages his sides to play football so we can expect a good match in front of what will be a big crowd for what is a big game."
Derry City v Finn Harps, Maginn Park, 7.45pm
A huge night for Ollie Horgan's men. They go to Maginn Park desperate for something to keep their hopes of staying in the Premier Division alive .
At it stands Harps are four points from safety and second from bottom. Sligo Rovers' win over Bohs lifted the Bit O’Red out of the bottom three and for now it leaves Galway United as the other team in the relegation zone, with Drogheda United already down.
Harps won 2-0 at Maginn Park back in April before two late goals in Ballybofey at the end of July saw them lose by a the same score to the Candystripes. They need to pull this out of the bag.
Derry City: To follow
Finn Harps: Horgan took a chance on the fitness of Ethan Boyle, Paddy McCourt for the Dundalk game and they were forced out of the action early. They're out tonight, as is Packie Mailey.
Ben Doherty (Derry City): "Friday night’s game will be a massive," he told the Derry Journal. "Even for the fans it’s a massive game because they want the bragging rights. It’s a rivalry and no team wants to lose it."
Ollie Horgan (Finn Harps): "We are still very much in a position to keep our place in the Premier Division and that’s where I said we would happy to be when the season started. We have three games left but I’m not looking beyond Derry. It’s going to take a mighty performance to get anything from Maginn Park."
Shamrock Rovers v Sligo Rovers, Tallaght Stadium, 8pm
It's the battle of the Rivers in Tallaght and do or die for Sligo. They dug out a huge 1-0 win against Bohs last time out to squeeze out of the bottom three. Another win here would put them tantalisingly close to safety but their hosts won't want to encourage Derry's surge for third.
The Hoops are four points clear of the Candystripes who lie in fourth having played a game less.
Dave Webster is ruled out after breaking his foot in the mid-week cup tie with Dundalk. The centre-half won't play again this season. Roberto Lopes broke his nose but will be available to play. The former Bohs man will get an operation at the end of the season. Lee Grace and Trevor Clarke are carrying knocks but both will be available for selection for Rovers
Graham Burke remains out as he recovers from injury but may yet feature before the end of he season.
Sligo Rovers: Michael Schlingermann is ruled out with a neck injury. Jamie McDonagh returns from international duty while Gary Boylan has overcome a foot problem
Stephen Bradley (Shamrock Rovers): "We need to learn our lessons [losing in extra time to Dundalk on Tuesday] because we're going to be involved in a lot of big games over the coming years and we need to learn how to manage them better.
"It was disappointing to lose but we'll be fine, we'll get ready and we'll go again for Sligo. We want third, that’s our aim. It’s been about improving on last year and third, with a cup final and semi-final does that for us."
Gerard Lyttle (Sligo Rovers): "As always we focus on ourselves and our game plan. Our form is good at home and away. The Galway game was the one blip on that but we've gone to difficult places and won. We rectified that last week and our own game plan is our priority going into this one."