Bournemouth v Leicester
Bournemouth look set to be without midfielder Harry Arter again because of an Achilles problem.
Dan Gosling is also a doubt after taking a heavy knock towards the end of the defeat at Everton and will be assessed. Tyrone Mings has a back problem.
Leicester are keeping an eye on the fitness of Jamie Vardy, who has been managing a hip problem and only trained for the first time this week on Thursday. Robert Huth, who underwent ankle surgery in the summer, and midfielder Matty James (Achilles) remain out.
Last five league matches: AFC Bournemouth L L L W L; Leicester W L L D L
Chelsea v Manchester City
Eden Hazard is expected to start in the Premier League for the first time this season.
Defender David Luiz completes his three-match domestic suspension for his dismissal against Arsenal, with Andreas Christensen poised to deputise. Danny Drinkwater (calf) is out.
Manchester City will be without Sergio Aguero after the striker suffered rib injuries in a car crash on Thursday.
Benjamin Mendy is a long-term casualty after rupturing an anterior cruciate ligament. Vincent Kompany, who has missed the last six games, remains on the sidelines with a calf injury.
Last five league matches: Chelsea W W W D W; Man City D W W W W
Huddersfield v Tottenham Hotspur
Huddersfield head coach David Wagner will select from an unchanged squad. Wagner has no new injury concerns but club record signing Steve Mounie (foot) is still out having missed the last three games.
Fellow striker Collin Quaner (knee), plus midfielders Kasey Palmer (hamstring) and Danny Williams (foot) remain sidelined.
Christian Eriksen has recovered from illness and is available but Serge Aurier is suspended following his red card last week.
Mousa Dembele remains sidelined with an ankle injury while Danny Rose and Victor Wanyama are both still missing with knee problems.
Last five league matches: Huddersfield W D L D D; Tottenham Hotspur L D W D W
Manchester United v Crystal Palace
Jose Mourinho expects Manchester United to be without Michael Carrick, Paul Pogba, Marcos Rojo and Zlatan Ibrahimovic.
Phil Jones and Antonio Valencia will be assessed along with Maraoune Fellaini and Anthony Martial.
Freddie Ladapo could solve Crystal Palace's striker crisis after Christian Benteke was ruled out for at least six weeks with knee trouble.
Bakary Sako could be pressed into service as a makeshift striker. Ruben Loftus-Cheek has a thigh problem, and James Tomkins is ill.
Last five league matches: Man Utd W W D W W; Crystal Palace L L L L L
Stoke v Southampton
Bruno Martins Indi (groin), Ryan Shawcross (back) and both Geoff Cameron and Kevin Wimmer (both hamstring) are rated doubtful for Stoke.
Mark Hughes does have Kurt Zouma back after the Frenchman was ineligible to face his parent club Chelsea last weekend.
Virgil van Dijk could remain on the bench for Southampton. Saints boss Mauricio Pellegrino may be able to select from an almost full-strength squad, with Matt Targett working hard to shake off ankle trouble.
Last five league matches: Stoke W D D L L; Southampton W D L W L
West Brom v Watford
West Brom boss Tony Pulis is likely to have an unchanged squad. Nacer Chadli (thigh) and Oliver Burke (hamstring) have resumed training but are lacking match sharpness.
James Morrison, James McClean, Matt Phillips and Salomon Rondon are pushing for starts.
Watford will have defender Miguel Britos available again following a three-match supsension, but Nathaniel Chalobah needs surgery on a knee injury.
Sebastian Prodl (thigh) is stepping up his rehabilitation, but Younes Kaboul (hamstring) is not expected back until after the international break.
Last five league matches: West Brom W D L D L; Watford W D W L W
West Ham v Swansea
Manuel Lanzini (knee) and Michail Antonio (groin) are in the West Ham squad after both returned to fitness. Pedro Obiang is still missing with a muscle injury and James Collins has ankle trouble.
Swansea skipper Leon Britton is under consideration following his full recovery from a knee injury.
On-loan Renato Sanches and Tammy Abraham could also return as Ki Sung-yueng (knee) and Nathan Dyer (Achilles) prepare to build their fitness in an Under-23 game against Celtic.
Last five league matches: West Ham L L W D L; Swansea L W L D L
Arsenal v Brighton (Sunday)
Arsenal are expected to revert to a full-strength team for the game after Laurent Koscielny, Aaron Ramsey, Mesut Ozil, Alexis Sanchez, Granit Xhaka, Alexandre Lacazette, Sead Kolasinac, Hector Bellerin, Petr Cech and Nacho Monreal were all rested for the Europa League clash at BATE Borisov.
Brighton will be without Tomer Hemed, who starts a three-match ban. Sam Baldock is still missing with a calf problem but Glenn Murray has an outside chance of being involved after an ankle injury.
Last five league matches: Arsenal L L W D W; Brighton L D W L W
Everton v Burnley (Sunday)
Everton will assess centre-backs Michael Keane (foot) and Phil Jagielka (hamstring).
Oumar Niasse is set to return having missed the 2-2 Europa League draw with Apollon Limassol. Wayne Rooney injured his hand in that match but is fit to play.
Jon Walters (knee) and Nahki Wells (ankle) will again sit out for Burnley. Dean Marney, who has been sidelined since January after rupturing knee ligaments, is back in training.
Last five league matches: Everton D L L L W; Burnley L D W D D
Newcastle v Liverpool (Sunday)
Newcastle striker Aleksandar Mitrovic is available after suspension having missed the last three games.
Florian Lejeune returns to contention after shaking off an ankle injury, but manager Rafael Benitez otherwise has no fresh injury concerns with only fellow defenders Paul Dummett (hamstring) and Massadio Haidara (knee) missing.
Liverpool forward Sadio Mane is set to start after returning from a domestic suspension.
Georginio Wijnaldum could face his former club at the expense of Emre Can. Adam Lallana (thigh) is running outside again but is still several weeks from a comeback.
Last five league matches: Newcastle L W W W L; Liverpool W W L D W