Duvan Zapata won his family battle by inspiring Sampdoria to a 2-0 win over AC Milan in Serie A.
The Colombian striker was up against cousin Cristian Zapata and it was a mistake by the Milan defender which gifted him the opening goal midway through the second half.
Zapata had missed a couple of chances in the first half to give the lead to dominant Sampdoria, who were awarded an early penalty when a cross from Ivan Strinic hit the arm of Franck Kessie but the referee changed his decision after reviewing the incident.
Milan improved after the break but Suso curled a shot high and wide and Nikola Kalinic blazed over the crossbar from 10 yards.
Ricardo Alvarez added to Zapata's strike with a breakaway goal in stoppage time, just seconds after coming on as a substitute.
Lazio bounced back from last weekend's heavy home defeat to Napoli with a 3-0 victory at Verona.
Ciro Immobile (above right) took his goal tally for the season into double figures with two more efforts, the second from the penalty spot, while Adam Marusic was also on target.
Inter Milan remain on the coattails of leaders Napoli and Juventus after leaving it late to beat Genoa 1-0 at San Siro.
Danilo D'Ambrosio struck three minutes from time before late red cards for Stephane Omeonga and Adel Taarabt saw the visitors finish the match with nine men.
Roberto Inglese and Mariusz Stepinski scored the goals at Cagliari to give Chievo their first win since the opening weekend of the campaign.
The hosts played the final seven minutes with 10 men after Fabio Pisacane was sent off.
Crotone won the battle between the bottom two teams as goals either side of half-time from Rolando Mandragora and Marcus Rohden (above) gave them a first league victory of the season.
It was enough to move them out of the bottom three but Benevento remain at the foot of the table and without a point.
In La Liga, Simone Zaza was Valencia's hero once again as he snatched victory in a five-goal thriller at Real Sociedad in which both sides were reduced to 10 men.
Zaza, who scored a hat-trick in last weekend's 5-0 demolition of Malaga, struck five minutes from time after Igor Zubeldia and Geoffrey Kondogbia had been dismissed to clinch a 3-2 win as the visitors produced a stunning display of counter-attacking football.
Espanyol registered only their second win of the season by beating struggling Deportivo de La Coruna 4-1.
They took the lead after just five minutes when Leo Baptistao headed in a cross from Victor Sanchez.
The advantage was doubled in the 22nd minute when Depor defender Alejandro Arribas deflected a corner onto his own net.
Depor pulled one back through Celso Borges eight minutes into the second half, but Gerard Moreno made the points safe with a penalty and a late tap-in.
Getafe thrashed Villarreal 4-0 to secure their first home win of the season.
The hosts had suffered one-goal defeats to Sevilla and Barcelona at the Coliseum Alfonso Perez but got off the mark at the third attempt and ended Villarreal's four-match unbeaten run in all competitions.
Angel Rodriguez gave Getafe a 54th-minute lead when he headed in Juan Cala's flick-on at the back post and - 10 minutes later - Jorge Molina pounced on Ruben Semedo's hesitancy to steal possession and slot past Mariano Barbosa.
Markel Bergara forced in a third in the 67th minute after Barbosa had somehow kept out Cala's close-range header and Angel nodded in his second in stoppage time from Faycal Fajr's corner.
Celta Vigo earned their first away win since April by swatting aside Eibar 4-0, and Leganes ended their three-match winless run with a 2-0 victory at Las Palmas.
Bayer Leverkusen's Lucas Alario scored and set up another goal in a 3-0 victory over Hamburg SV on Sunday in a memorable debut for the Argentine striker, whose Bundesliga start was delayed over a contract dispute with former club River Plate.
The 24-year-old Alario, who joined for a reported fee of €19m, had been training with Leverkusen for weeks after his buyout clause was activated in August.
Leverkusen, however, had to wait until Thursday for a final ruling by world soccer body FIFA that cleared Alario to play, after the Argentine football federation and River Plate had refused to release the player.
Cologne earned their first point of the season after their 0-0 draw at in-form Hanover 96.
Undefeated Hanover, who are fourth on 12 points, should have scored in a dominant first half and wasted more opportunities through Salif Sane and Martin Harnik after the break.
But Cologne held on for their first point after five straight losses.
Borussia Dortmund are top on 16 points, after their 6-1 demolition of Borussia Moenchengladbach on Saturday.
They are two ahead of Hoffenheim, 2-0 winners over Schalke 04, and three clear of champions Bayern Munich, who wasted a two-goal lead in a 2-2 draw against VfL Wolfsburg on Friday.
Jonathan Bamba's penalty rescued a 2-2 draw for St Etienne at home to Rennes in Ligue 1.
Benjamin Bourigeaud drove Rennes into the lead from outside the area four minutes before half-time.
The hosts responded almost immediately, Gabriel Silva striking from a corner in first-half stoppage time.
Wahbi Khazri scored from the penalty spot eight minutes into the second half but Bamba responded in kind with 20 minutes remaining.
St Etienne finished with 10 men after Silva was sent off for a stoppage-time foul on Morgan Amalfitano.
Nantes came from behind to win at Strasbourg for a third straight league victory.
The 2-1 success, which extended Claudio Ranieri's side's unbeaten run to five Ligue 1 matches, came courtesy of goals from Adrien Thomasson and Leo Dubois after Nuno Da Costa had put the hosts ahead.
Nantes are up to fifth in the table, while Strasbourg remain bottom following a fourth successive defeat.
In the Eredivisie, Jurgen Locadia plundered four goals as PSV Eindhoven trounced FC Utrecht 7-1 to climb to the top of the table.
Luigi Bruins did the damage as Excelsior got off to a lightning start in their trip to AZ Alkmaar.
Bruins picked himself up to dispatch a second-minute penalty after being fouled inside the box by Jonas Svensson, and then repeated the dose just six minutes later after Ron Vlaar had been penalised for a challenge on Kevin Vermeulen.
AZ battled manfully for a way back into the game, but met stubborn resistance as goalkeeper Birkir Kristinsson kept out an injury-time header from Wout Weghorst to cap a 2-0 win.
Vitesse Arnhem maintained their excellent start to the season as an impressive first-half display laid the foundation for a 2-1 win at Ajax.
Groningen striker Oussama Idrissi's second-half header was enough to clinch a 1-0 home win over FC Twente, while VVV-Venlo needed a 69th-minute equaliser from midfielder Clint Leemans to cancel out Kingsley Ehizibue's first-half strike and secure a 1-1 draw with Zwolle.