FIFA has voted to replace its chief ethics investigator and top judge in a move the pair have claimed signals an end to the organisation's reform efforts.
Swiss investigator Cornel Borbely and German judge Hans-Joachim Eckert, who have combined to ban numerous football officials in recent years, will be removed following sweeping changes announced by the ruling council of world football's governing body.
They will be replaced by Colombian prosecutor Maria Claudia Rojas and Greek judge Vassilios Skouris, who was president of the European Court of Justice from 2003 to 2015.
Both Borbely and Eckert had said they wished to continue their work and branded their departures damaging to world football.
The FIFA Council decisions were announced in Bahrain on Tuesday, two days before the 67th FIFA Congress.
A statement from Borbely and Eckert read: "Their impending removal at the FIFA Congress will greatly set back the work of the ethics commission and means the de facto end of FIFA's reform efforts.
"It must be assumed therefore that in the medium and long term the whole of world football will suffer because of this decision.
"The work of the credible and independent ethics committee was and is an important part of the FIFA reforms, on which the trust of the public and FIFA stakeholders should have been rebuilt."
The statement said that a loss of confidence in FIFA's commitment to reform was now "inevitable" and the "already-battered image" of world football's governing body would be tarnished yet further.
It added that the removal of Borbely and Eckert was "obviously politically motivated".
It said: "It seems the FIFA hierarchy has valued its own and political interests higher than the long-term interests of FIFA."
Aside from the personnel changes, FIFA also confirmed how many slots each of its six confederations would get at the 48-team World Cup in 2026.
As widely anticipated, UEFA sees its allocation grow from 13 to 16, with the other regional bodies all seeing more substantial increases.
Two of the new slots will be decided by what FIFA described in a statement as an "intercontinental play-off tournament involving six teams", while the host's automatic place will be deducted from its confederation's quota.
In the event of co-hosts, as looks increasingly likely for 2026, the number of automatic places will be decided by the council.
On the subject of who will host the 2026 tournament, the council decided against ending the race now by simply giving it to the joint North American bid from Canada, Mexico and the United States but rivals from other confederations only have until August to declare their hands.
The short time-frame means the North American bid is almost guaranteed of victory, which should be confirmed at next year's congress.
Other decisions reached by the council include lifting the ban on Iraq being able to play matches, providing the security situation remains stable in the proposed venues, and London being named as the host of the Best FIFA Football Awards 2017 on 23 October.