Shane Long has been ruled out of the Republic of Ireland's World Cup qualifier against Austria on Saturday week, while Dundalk pair Daryl Horgan and Andy Boyle are included in the squad for the first time.
David McGoldrick has been recalled in attack, but there is no place for Shane Long or Daryl Murphy due to injury.
Five goalkeepers have been named in the squad, with just four strikers listed. Colin Doyle returns to the squad alongside Darren Randolph, Keiren Westwood, Ian Lawlor and Danny Rogers.
Jon Walters, Adam Rooney, Kevin Doyle and McGoldrick are the strikers, with James McClean an option for attack after his two goals against Moldova.
Horgan has been in sensational form for the Premier Division champions, including scoring 10 goals in the league.
Boyle, linked with a move to Barnsley after another strong campaign with Stephen Kenny's men, is also included for the first time in the 35-man squad.
O'Neill revealed at a press conference in Dublin this morning that James McCarthy is doubtful and will be assesed next week.
Harry Arter is back in the squad after overcoming injury as his good form with Bournemouth continues.
Just one of the reasons Daryl Horgan has been called up to the Republic of Ireland squad. pic.twitter.com/VZb7i2ezcA
— Soccer Republic (@SoccRepublic) November 2, 2016
Republic of Ireland Provisional squad:
Goalkeepers: Darren Randolph (West Ham United), Keiren Westwood (Sheffield Wednesday), Colin Doyle (Bradford City), Ian Lawlor (Manchester City), Danny Rogers (Falkirk)
Defenders: Seamus Coleman (Everton), Cyrus Christie, Richard Keogh, Alex Pearce (Derby County), John O'Shea (Sunderland), Ciaran Clark (Newcastle United), Paul McShane (Reading), Shane Duffy (Brighton & Hove Albion), Andy Boyle (Dundalk), Stephen Ward (Burnley)
Midfielders: Aiden McGeady (Preston North End), James McClean (West Bromwich Albion), Jeff Hendrick (Burnley), James McCarthy (Everton), Stephen Quinn (Reading), Glenn Whelan (Stoke City), Harry Arter (Bournemouth), Eunan O'Kane (Leeds United), David Meyler (Hull City), Stephen Gleeson (Birmingham City), Conor Hourihane (Barnsley), Robbie Brady, Wes Hoolahan (Norwich City), Callum O'Dowda (Bristol City), Jonathan Hayes (Aberdeen), Daryl Horgan (Dundalk)
Forwards: Jonathan Walters (Stoke City), Adam Rooney (Aberdeen), Kevin Doyle (Colorado Rapids), David McGoldrick (Ipswich Town).
