Athletic Bilbao's Raul Garcia headed the only goal of a near-farcical first leg of their all-Spanish last-16 Europa league tie with Gary Neville's Valencia.
Garcia glanced in from a free-kick after 20 minutes to give Bilbao the least they deserved from a match played in torrential rain and on a saturated pitch at the Estadio de San Mames.
Holders Sevilla played out a goalless draw at Basle in the first leg of their Europa League last-16 clash after having Steven Nzonzi sent off three minutes from time for a second bookable offence.
The Spanish side had dominated the second half, with Basle goalkeeper Tomas Vaclik making good saves to deny Nzonzi, Kevin Gameiro and Yevhen Konoplyanka.
The fourth Spanish side to have reached the last 16, Villarreal, ran out 2-0 winners over 10-man Bayer Leverkusen at El Madrigal.
Cedric Bakambu scored both goals, getting his side off to a flying start with a fourth-minute opener and then doubling the lead 11 minutes into the second half.
Leverkusen had goalkeeper Bernd Leno to thank for a fine late save from Leo Baptistao but their night ended on a sour note when Tin Jedvaj received a second booking in injury time.
Sparta Prague and Lazio drew 1-1 in the Czech capital. Martin Frydek rewarded Sparta for a bright start with a superb opener after 13 minutes but Marco Parolo pounced on a rebound to equalise before the break.
Lazio went the closest to a winner with Antonio Candreva hitting the bar.
Shakhtar Donetsk claimed a 3-1 win over Anderlecht in Lviv. Two goals in the space of three minutes from Taison and Olexandr Kucher gave the Ukrainian side the lead during a first half in which they also hit the post through Eduardo.
Anderlecht rallied after the break and pulled one back through Frank Acheampong but Eduardo's 79th-minute effort ensured a healthy lead for Shakhtar.
Mehmet Topal scored an 82nd-minute winner as Fenerbahce beat Braga 1-0 in Istanbul. The decisive strike came just moments after Fenerbahce goalkeeper Volkan Demirel made a fine save to deny Josue at the other end.
