All games 3pm unless stated
Chelsea (15) v Liverpool (9) 12.45pm
Diego Costa and Pedro will undergo late fitness tests. Costa damaged ribs in Tuesday's Capital One Cup penalty shoot-out defeat at Stoke, while Pedro has been absent in recent games with an undisclosed knock. Midfielder Nemanja Matic is available after serving a one-match suspension for his dismissal at West Ham last Saturday, but goalkeeper Thibaut Courtois (knee) and defender Branislav Ivanovic (hamstring) remain out.
Striker Christian Benteke returns to Liverpool's squad. He was rested for the Capital One Cup victory over Bournemouth because of a knee niggle but has trained since and will go back into the side. Defender Kolo Toure is out with a hamstring injury sustained in midweek, midfielder James Milner returns from suspension while forward Roberto Firmino is pushing for a starting spot.
Last season: Chelsea 1 Liverpool 1, Liverpool 1 Chelsea 2
Last five league matches: Chelsea W D L W L; Liverpool D W D D D
Top scorers (all competitions): Willian (Chelsea) 4; Danny Ings, Christian Benteke (Liverpool) 3
Crystal Palace (7) v Manchester United (4)
Jason Puncheon will be fit for Crystal Palace while Yohan Cabaye needs a late fitness check. Puncheon missed the midweek Capital One Cup defeat at Manchester City through illness and fellow midfielder Cabaye sat out with a knock. Full-backs Pape Souare and Joel Ward are short of fitness and strikers Marouane Chamakh (hamstring) and Connor Wickham (calf) remain out.
Manchester United will be without injured trio Memphis Depay, Antonio Valencia and James Wilson. Depay and Wilson were both injured in the Capital One Cup defeat to Middlesbrough while Valencia hurt his foot in the Manchester derby last weekend. Ashley Young is pushing for a recall after coming off the bench against Middlesbrough having missed the previous three games while Luke Shaw and Paddy McNair are long-term absentees.
Last season: Crystal Palace 1 Man Utd 2, Man Utd 1 Crystal Palace 0
Last five league matches: Crystal Palace L W W L L; Man Utd W W L W D
Top scorers (all competitions): Yohan Cabaye, Dwight Gayle (Crystal Palace) 4; Anthony Martial, Wayne Rooney (Man Utd) 6
Manchester City (1) v Norwich (16)
Manchester City playmaker David Silva is not fit to return. The Spain international has been out for the past fortnight with an ankle injury but could be back in contention for next week's Champions League trip to Sevilla. Right-back Pablo Zabaleta suffered medial ligament damage this week and is likely to be out until after the November international break. Sergio Aguero, Samir Nasri, Gael Clichy and Fabian Delph are still sidelined.
Norwich will be without on-loan Liverpool defender Andre Wisdom (knee). Forward Dieumerci Mbokani is also a doubt having missed the midweek Capital One Cup defeat at Everton because of illness. Midfielder Youssouf Mulumbu returned from pre-season foot surgery to play at Goodison Park, so may be involved in the squad again.
Last season: No corresponding fixture
Last five league matches: Man City L L W W D; Norwich D D L L L
Top scorers (all competitions): Sergio Aguero (Man City) 8; Nathan Redmond (Norwich) 4
Newcastle (19) v Stoke (14)
Newcastle skipper Fabricio Coloccini is available after a successful appeal against his red card at Sunderland. The Argentinian was sent off in first-half injury time for a challenge on striker Steven Fletcher, but saw his dismissal rescinded after launching a challenge. However, midfielder Jack Colback could be out for up to six weeks after damaging his knee at the Stadium of Light.
Stoke's Marc Muniesa will miss the trip to Tyneside on Saturday with a hamstring problem which is expected to keep him out for a month. Muniesa joins Geoff Cameron (thigh) on the sidelines after sustaining the injury during Tuesday's Capital One Cup triumph against Chelsea, while Phil Bardsley is suspended following his sending-off in that game, but their fellow defender Erik Pieters is available again, having served a ban.
Glen Johnson and Bojan Krkic are also set to be back involved after sitting out the cup tie, as is the on-loan Marco van Ginkel, who was ineligible against his parent club. Fit-again captain Ryan Shawcross should retain his place after what was his first appearance of the season.
Last season: Newcastle 1 Stoke 1, Stoke 1 Newcastle 0
Last five league matches: Newcastle L D L W L; Stoke D W W W L
Top scorers (all competitions): Georginio Wijnaldum (Newcastle) 6; Jonathan Walters (Stoke) 4
Swansea (12) v Arsenal (2)
Swansea are at full strength after Federico Fernandez was cleared over his Villa Park clash with Micah Richards. Wide man Wayne Routledge has returned to training this week after a calf problem.
Arsenal will be without forward Theo Walcott (calf) as well as Alex Oxlade-Chamberlain and Aaron Ramsey (both hamstring). Costa Rica international Joel Campbell is expected to be given his opportunity on the right flank. Captain Mikel Arteta (ankle) also misses out and goalkeeper David Ospina (shoulder) is still not available. Midfielder Jack Wilshere (fibula), forward Danny Welbeck and Czech playmaker Tomas Rosicky (both knee) all continue their rehabilitation.
Last season: Arsenal 0 Swansea 1, Swansea 2 Arsenal 1
Last five league matches: Swansea D L D L W; Arsenal L W W W W
Top scorers (all competitions): Andre Ayew (Swansea) 5; Alexis Sanchez (Arsenal) 7
Watford (13) v West Ham (3)
Watford boss Quique Sanchez Flores is hoping Jose Manuel Jurado may be fit in time. The midfielder has been missing with a hamstring strain but has returned to training and could be involved against the Hammers. Former West Ham midfielder Valon Behrami will be pushing for a start after coming off the bench in the win over Stoke last week following a calf injury, while Joel Ekstrand (knee) and Tommie Hoban (groin) are still out.
West Ham boss Slaven Bilic could welcome back defender Winston Reid after the New Zealand international missed the win over Chelsea with a thigh issue. Victor Moses is also back after being ineligible against his parent club but Alex Song (ankle) is still missing while Bilic has to decide whether to hand last weekend's match-winner Andy Carroll his first start since January.
Last season: No corresponding fixture
Last five league matches: Watford W L D L W; West Ham W D D W W
Top scorers (all competitions): Odion Ighalo (Watford) 5; Dimitri Payet (West Ham) 5
West Brom (10) v Leicester (5)
West Brom boss Tony Pulis confirmed they have "one or two" doubts to be assessed but did not name the players. Goalkeeper Ben Foster remains a long-term absentee with the serious knee injury he suffered in March but midfielder James Morrison could return after an ankle injury, with last week's 1-0 win at Norwich coming too soon for the Scotland international.
Leonardo Ulloa is expected to return from injury. City boss Claudio Ranieri chose not to risk Ulloa, who has recently been nursing a thigh strain, in the Capital One Cup at Hull but the Argentinian striker should be back in the squad at the Hawthorns. Ranieri will make wholesale changes on Saturday after swapping 10 players in midweek, with the Premier League's leading scorer Jamie Vardy among those set to be recalled to the starting line-up.
Last season: West Brom 2 Leicester 3, Leicester 0 West Brom 1
Last five league matches: West Brom W L L W W; Leicester D L W D W
Top scorers (all competitions): Saido Berahino (West Brom) 3; Jamie Vardy (Leicester) 10
Everton (11) v Sunderland (18) 1.30pm
Right-back Seamus Coleman is a major doubt because of a stomach bug. Midfielder Gareth Barry returns from suspension while goalkeeper Tim Howard will be among the players to come back in after manager Roberto Martinez shuffled his pack for the Capital One Cup win over Norwich in midweek. Left-back Leighton Baines and midfielder Muhamed Besic were both set to return to full training on Friday as they work their way back to match fitness while captain Phil Jagielka remains sidelined by a knee injury.
Central defenders John O'Shea (hamstring) and Younes Kaboul (groin), and midfielder Ola Toivonen (also groin) are doubtful for Sunderland after limping out of last weekend's 3-0 victory over Newcastle, while striker Fabio Borini remains a concern after missing the derby with an ankle problem. None of the four have trained this week but they will be given until the last minute to prove their fitness, with Sebastian Coates and Wes Brown standing by to fill key positions at the back if O'Shea and Kaboul do not make it.
Last season: Everton 0 Sunderland 2, Sunderland 1 Everton 1
Last five league matches: Everton D W D L L; Sunderland L L D L W
Top scorers (all competitions): Romelu Lukaku (Everton) 7; Jermain Defoe (Sunderland) 5
Southampton (8) v Bournemouth (17) 4pm
Southampton forwards Jay Rodriguez and Shane Long remain sidelined. Rodriguez is over the cruciate ligament injury that kept him out for 16 months but is struggling with pain in his feet and is not due back in training until next week. Long has an injured ankle, while Florin Gardos and Fraser Forster have long-term knee complaints.
Harry Arter is in line for his first Premier League start of the season after playing 71 minutes of Bournemouth's Capital One Cup defeat at Liverpool. The midfielder's return is a timely boost to manager Eddie Howe, who remains without long-term absentees Callum Wilson, Max Gradel and Tyrone Mings (all knee), the former perhaps his biggest goal threat and the other two the club's most expensive ever signings. Out-of-form goalkeeper Artur Boruc is still nursing a thigh problem, so Adam Federici is again expected to start in his absence. Captain Tommy Elphick is also still out with an ankle injury, albeit not for the long term.
Last season: No corresponding fixture
Last five league matches: Southampton L W W D D; Bournemouth W L D L L
Top scorers (all competitions): Graziano Pelle (Southampton) 8; Callum Wilson (Bournemouth) 5
Tottenham (6) v Aston Villa (20) 8pm
Midfielder Ryan Mason is in line for his first Tottenham start in six weeks. The England international suffered a knee injury against Sunderland last month but came off the bench at Bournemouth last week to bolster Mauricio Pochettino's options. Summer signing Son Heung-min (foot) remains absent as does Federico Fazio (hamstring) while ankle injuries keep Nabil Bentaleb, Nacer Chadli and Alex Pritchard sidelined.
Micah Richards is awaiting the outcome of a Football Association investigation and could be banned. The captain has admitted a charge of improper conduct following an incident in the tunnel after Saturday's 2-1 defeat to Swansea and the FA is set to decide his punishment. Joleon Lescott is expected to make a comeback after missing Wednesday's 2-1 Capital One Cup defeat at Southampton through injury, while Idrissa Gana and Adama Traore should return to the squad as they were rested for the St Mary's trip.
Last season: Tottenham 0 Aston Villa 1, Aston Villa 1 Tottenham 2
Last five league matches: Tottenham W W D D W; Aston Villa L L L L L
Top scorers (all competitions): Erik Lamela, Harry Kane (Tottenham) 4; Scott Sinclair (Aston Villa) 6