Borussia Dortmund's Marco Reus has been ruled out for a month with the ankle ligament injury he suffered during Germany's 2-1 win over Scotland on Sunday.
The 25-year-old is likely to miss Germany's next two Euro 2016 Group D qualifiers against Poland and the Republic of Ireland next month.
Germany will host Martin O’Neill’s side on Tuesday 14 October in Gelsenkirchen, three days after the world champions play away to rivals Poland.
Reus will also miss Dortmund's Champions League ties with Arsenal and Anderlecht as well as up to five Bundesliga encounters due to the injury.
The attacking midfielder was ruled out of this summer's World Cup after he damaged ankle ligaments against Armenia immediately prior to the national team's departure for Brazil in June.
His latest injury affects the same ankle.
A statement on the Bundesliga club's website on Monday confirmed: "A scan carried out by BVB's club doctor Markus Braun at Dortmund's Knappschaft Hospital on Monday revealed that Reus suffered a sprained ankle as well as a partially torn ankle ligament and is expected to be sidelined for four weeks."
Reus made a surprisingly quick return to action following his injury in June, featuring as captain in Dortmund's 4-1 DFB-Pokal win over Stuttgarter Kickers only two months into what was expected to be a three-month recovery.
He also played in Dortmund's first two Bundesliga matches and appeared to have made a full recovery, only to suffer another injury following a challenge by Scotland's Charlie Mulgrew moments from the end of Sunday's European Championship qualifier in his home Dortmund stadium.
"It's incredible the bad luck he has had in a Germany shirt," said Bayern Munich midfielder and Germany team-mate Thomas Muller on Sunday night.
