Shamrock Rovers became the first club in Setanta Sports Cup history to progress after losing the opening leg of the tie as they beat Coleraine 2-0.
The Hoops progressed to the quarter-finals after beating The Bannsiders in the return leg at the Coleraine Showgrounds having lost the first leg 1-0 at Tallaght Stadium last week.
Mark Quigley scored the opening goal of the night after five minutes, before Ciaran Kilduff wrapped up the result and the outcome of the two-legged tie with an injury-time goal as extra-time loomed.
Drogheda United also progressed to the quarter-finals with a very convincing 5-0 victory over Portadown at Shamrock Park.
Mick Cooke’s side won the tie 8-2 on aggregate after goals from Alan Byrne, Paul O’Conor, Gavin Brennan, David Cassidy and Philip Hand made sure that Drogheda’s place in the quarter-final hat was never in doubt.
Cork City are also through to the quarter-finals after goals from Daryl Horgan and Danny Furlong helped Tommy Dunne’s side to a 2-2 draw with Cliftonville at Solitude.
Liam Boyce and Stephen Garrett were on target for the home side but the Reds were always fighting a losing battle having lost the first leg 4-0 at Turner’s Cross. City finished the game with ten men as Kalen Spillane received a late red card.
Glentoran were the only Irish League side to secure a place in the quarter-finals as they beat St Patrick’s Athletic 1-0 at The Oval.
Martin Murray grabbed the only goal of the game as Glentoran went through 1-0 on aggregate after the two sides played out a scoreless draw at Richmond Park last week.
Sligo Rovers v Glentoran
Cork City v Crusaders
Derry City v Drogheda United
Shamrock Rovers v Linfield