Team news and squads added when available.
QPR v TOTTENHAM (12.45)
QPR defender Ryan Nelsen will play in the Loftus Road clash.
Nelsen has agreed to manage Major League Soccer side Toronto FC but a date has yet to be set for his departure, with manager Harry Redknapp hoping he stays until the end of the season.
Striker Junior Hoilett (hamstring) and midfielder Samba Diakite (African Nations Cup) are unavailable, while forwards Andrew Johnson (knee) and Bobby Zamora (hip) have long-term injuries.
Tottenham manager Andre Villas-Boas has no fresh injury concerns.
Defenders William Gallas (calf) and Younes Kaboul (knee) are the only players unavailable to the Portuguese.
Togo striker Emmanuel Adebayor will play his last game for the club before departing to the African Nations Cup.
QPR squad: Green, Cesar, Murphy, Cerny, Onuoha, Hill, Nelsen, Ferdinand, Mbia, Park, Fabio, Derry, Granero, Taarabt, Faurlin, Wright-Phillips, Ephraim, Mackie, Cisse, Campbell.
Tottenham squad: Lloris, Friedel, Gomes, Walker, Naughton, Dawson, Vertonghen, Caulker, Assou-Ekotto, Lennon, Sigurdsson, Falque, Townsend, Livermore, Dempsey, Carroll, Mason, Huddlestone, Parker, Sandro, Dembele, Bale, Defoe, Adebayor.
ASTON VILLA v SOUTHAMPTON (3.00)
Aston Villa skipper Ron Vlaar could play some part in Saturday's home clash with Southampton after returning to training following a seven-week absence with a calf injury.
Midfielders Ashley Westwood (ankle) and Brett Holman (virus) are also back in contention for match between two struggling sides.
But striker Darren Bent (knee), defenders Chris Herd (foot) and Richard Dunne (groin), winger Marc Albrighton (metatarsal) and keeper Shay Given (hamstring) are ruled out.
Southampton will be without Jose Fonte and Adam Lallana when they travel to Villa Park.
The pair have knee injuries so will miss the trip to Villa Park, while Emmanuel Mayuka is unavailable after linking up with Zambia for the African Nations Cup.
There is good news in regards to Gaston Ramirez and Nathaniel Clyne, who return from a dead leg and knee complaint respectively.
Aston Villa squad: Guzan, Marshall, Lowton, Vlaar, Clark, Lichaj, Stevens, Bennett, Ireland, N'Zogbia, Bannan, Delph, Holman, Westwood, Benteke, Agbonlahor, Bowery, Weimann, Burke, Johnson, Williams, Carruthers.
Southampton squad: K Davis, Gazzaniga, Boruc, Clyne, Richardson, Stephens, Fox, Shaw, Yoshida, Hooiveld, Martin, Reeves, Ward-Prowse, Do Prado, Cork, Chaplow, De Ridder, Ramirez, Schneiderlin, S Davis, Puncheon, Lee, Lambert, Rodriguez.
EVERTON v SWANSEA (3.00)
Everton manager David Moyes is optimistic full-back Leighton Baines will be available for tomorrow's Barclays Premier League home clash with Swansea.
Baines has been nursing an ankle problem and Moyes says he is monitoring the England international's condition, but expects him to be fit for the Swans' visit to Goodison Park.
It remains to be seen whether or not forward Kevin Mirallas, sidelined recently by a hamstring injury, is ready to make his return to action.
Swansea manager Michael Laudrup has no new injury concerns ahead of his side's visit to Everton.
But the Dane may decide to make changes given the short turnaround from the 2-0 midweek win at Chelsea in the Capital One Cup.
Michel Vorm will return in goal while Kemy Agustien, Nathan Dyer and Danny Graham could all be handed starts with Swansea facing a third game in six days.
Everton squad: Howard, Jagielka, Distin, Heitinga, Baines, Oviedo, Naismith, Hitzlsperger, Osman, Pienaar, Fellaini, Jelavic, Mucha, Duffy, Neville, Anichebe, Vellios, Gueye, Coleman.
Swansea squad: Vorm, Bartley, Flores, Williams, Britton, Lita, Michu, Graham, Hernandez, Dyer, Routledge, Monk, Shechter, Moore, De Guzman, Tiendalli, Rangel, Ki, Tremmel, Agustien, Gower, Richards, Davies.
FULHAM v WIGAN (3.00)
Mahamadou Diarra and Kerim Frei are both unavailable for Fulham's match against West Brom , although manager Martin Jol can welcome back a number of players.
Mladen Petric, Damien Duff, Mark Schwarzer and John Arne Riise all return after missing last weekend's 1-1 FA Cup third round draw with Blackpool.
Diarra (knee) and Frei (pelvis) are out, though, while right-back Stephen Kelly is set to join Reading.
Midfielder Roger Espinoza is set to make his Wigan debut against Fulham.
The Honduras international, signed from Sporting Kansas City, stayed on the bench in last weekend's FA Cup tie against Bournemouth having only arrived in the UK two days before, but now has a week's training under his belt.
Fellow new boy Angelo Henriquez is pushing for a start after impressing as a substitute last weekend, but defenders Antolin Alcaraz (groin) and Adrian Lopez (hamstring) and midfielders Ben Watson (broken leg), Albert Crusat (knee) and Ryo Miyaichi (ankle) are all out.
Fulham squad: Schwarzer, Stockdale, Somogyi, Etheridge, Riether, Hangeland, Hughes, Senderos, Riise, Briggs, Dejagah, Baird, Sidwell, Karagounis, Kacaniklic, Duff, Richardson, Kasami, Ruiz, Rodallega, Berbatov, Petric.
Wigan squad: Al Habsi, Pollitt, Boyce, Caldwell, Ramis, Figueroa, Beausejour, Jones, Maloney, Espinoza, McCarthy, McArthur, Stam, McManaman, Di Santo, Henriquez, Boselli, Fyvie, Redmond, Mustoe, Orsula, Morris.
NORWICH v NEWCASTLE (3.00)
Norwich could have captain Grant Holt back from a hamstring problem for their clash with Newcastle at Carrow Road.
Steve Morison (thigh) remains sidelined, so Canada striker Simeon Jackson is pressing for a place in the side after scoring in last weekend's 3-0 FA Cup win at Peterborough and midfielder Jonny Howson is expected to shake off a virus.
Defender Steven Whittaker (hip) and winger Andrew Surman (hip) continue their rehabilitation, while England goalkeeper John Ruddy remains a long-term absentee after surgery on his thigh injury.
Fabricio Coloccini is set to return to the Newcastle line-up despite persistent rumours linking him with a move back to Argentina.
Magpies boss Alan Pardew will hand former Lille full-back Mathieu Debuchy his debut, while Papiss Cisse also returns after missing last week's FA Cup loss at Brighton.
Pardew's injury problems have eased with the news that Yohan Cabaye is expected to return to the bench after a groin strain, but Steven Taylor and Hatem Ben Arfa remain out and Shola Ameobi is suspended after his red card last week.
Norwich squad: Bunn, Garrido, Turner, Bassong, Martin, Tettey, Johnson, Snodgrass, Pilkington, Hoolahan, Holt, Rudd, Jackson, Howson, Fox, Barnett, R Bennett, E Bennett, Kane.
Newcastle squad: Krul, Elliot, Tavernier, Perch, Williamson, Coloccini, Debuchy, Santon, Gutierrez, Anita, Cabaye, Cisse, Bigirimana, Obertan, Sammy Ameobi, Amalfitano, Marveaux, Abeid, Ranger, Ferguson.
READING v WEST BROM (3.00)
New Reading signings Daniel Carrico and Hope Akpan are set to make their debut in their new side's clash with West Brom.
Jason Roberts continues to be troubled by his hip problem, while Hal Robson-Kanu is a doubt with a knee injury. Mikele Leigertwood could also miss out with an unspecified knock.
Alex McCarthy is making encouraging progress following shoulder surgery and should return before the end of the season.
West Brom winger Jerome Thomas is in contention to replace long term knee injury victim Zoltan Gera.
Thomas proved his fitness after an injury-hit start to the season during a loan spell at Leeds and appeared as a substitute during the Baggies FA Cup tie at QPR last weekend.
Defenders Jonas Olsson (groin), Steven Reid (ankle) and Goran Popov (hamstring) plus midfielder Claudio Yacob (hamstring) remain doubtful while Youssouf Mulumbu is on African Nations Cup duty with DR Congo.
Reading squad: Federici, Ugwu, Taylor, Gunter, Cummings, Pearce, Morrison, Mariappa, Shorey, Harte, McAnuff, Carrico, Akpan, Tabb, Karacan, Kebe, McCleary, Robson-Kanu, Leigertwood, Le Fondre, Hunt, Pogrebnyak.
West Brom squad: Foster, Myhill, Daniels, Jones, Reid, Olsson, McAuley, Tamas, Dawson, Popov, Ridgewell, Yacob, Dorrans, Thorne, Brunt, Morrison, Thomas, Odemwingie, Fortune, Long, Lukaku, Rosenberg, El Ghanassy.
STOKE v CHELSEA (3.00)
Stoke boss Tony Pulis has no fresh injury concerns ahead of Saturday's clash with Chelsea at the Britannia Stadium.
Defender Marc Wilson and midfielder Rory Delap, who have been sidelined by a broken leg and hernia problem respectively, remain the only definite absentees for the Potters.
Pulis is expected to shuffle his pack again after making changes for last weekend's 0-0 FA Cup third round draw at Crystal Palace, where the likes of goalkeeper Asmir Begovic and striker Kenwyne Jones were rested.
Captain John Terry is in Chelsea's squad for the Barclays Premier League game at Stoke, but will not start, interim manager Rafael Benitez said today.
Terry has been out since November due to knee ligament damage he suffered against Liverpool, but the defender came through 45 minutes of the Blues' Under-21 game against Fulham yesterday and will be on the bench tomorrow.
Goalkeeper Petr Cech will have a test on his groin injury, while Nigeria duo John Obi Mikel and Victor Moses are unavailable as they are at the African Nations Cup.
Stoke squad: Begovic, Shotton, Shawcross, Cameron, Huth, Upson, Wilkinson, Whelan, Nzonzi, Walters, Kightly, Etherington, Jones, Sorensen, Whitehead, Crouch, Jerome, Adam, Palacios, Owen.
Chelsea squad: Turnbull, Cech, Azpilicueta, Ferreira, Ivanovic, Luiz, Cahill, Terry, Cole, Bertrand, Lampard, Ramires, Mata, Oscar, Hazard, Marin, Piazon, Torres, Ba, Hilario.
SUNDERLAND v WEST HAM (3.00)
Sunderland boss Martin O'Neill will be without defenders Danny Rose and Carlos Cuellar.
The pair both suffered hamstring injuries during last weekend's 2-2 FA Cup third round draw at Bolton and will be missing for several weeks.
Central defender John O'Shea (also hamstring) and striker Stephane Sessegnon (ankle) both missed the game at the Reebok Stadium and have returned to light training - but O'Shea in particular remains a doubt, and new signing Alfred N'Diaye will be included if his international clearance comes through in time.
New West Ham striker Marouane Chamakh goes straight into the Hammers squad.
The 28-year-old Morocco international has been signed on loan from Arsenal and could make his West Ham debut at the Stadium of Light. Modibo Maiga is missing as he links up with Mali ahead of the African Nations Cup while fellow forward Andy Carroll (knee) is also absent.
Defender Joey O'Brien remains a doubt with a hamstring problem but George McCartney (knee) is definitely out.
Sunderland squad: Mignolet, Westwood, Bardsley, O'Shea, Kilgallon, Bramble, Gardner, Colback, McClean, Larsson, Johnson, Vaughan, N'Diaye, Sessegnon, Fletcher, Saha, Campbell, Wickham, McFadden.
West Ham squad: Jaaskelainen, Spiegel, O'Brien, Collins, Reid, Tomkins, McCartney, Potts, Spence, Demel, Taylor, Nolan, Noble, Collison, Diarra, Jarvis, J Cole, O'Neil, Vaz Te, C Cole, Chamakh.
MANCHESTER UNITED v LIVERPOOL (Sunday 1.30)
Nani and Anderson both return to the Manchester United squad for Sunday's high-octane encounter with Liverpool at Old Trafford.
The pair have been sidelined for 14 and eight games respectively with hamstring injuries but are available to bolster Sir Alex Ferguson's options.
Wayne Rooney (knee) is missing though and Phil Jones is also likely to be saved for Wednesday's FA Cup replay with West Ham.
Striker Daniel Sturridge is in contention for his Barclays Premier League debut for his new club at Manchester United having joined from Chelsea last week.
The 23-year-old scored on his first appearance in the FA Cup win at Mansfield on Sunday and could keep his place at Old Trafford, where, the likes of the rested Steven Gerrard, Jose Reina and Glen Johnson will all return.
Forward Fabio Borini is back in the squad having been sidelined since mid-October with a broken foot.
Manchester United squad: Lindegaard, De Gea, Smalling, Vidic, Ferdinand, Evans, Buttner, Evra, Cleverley, Giggs, Fletcher, Anderson, Scholes, Carrick, Kagawa, Young, Nani, Hernandez, Welbeck, Van Persie.
Liverpool squad: Reina, Wisdom, Agger, Skrtel, Johnson, Gerrard, Lucas, Allen, Sterling, Sturridge, Suarez, Jones, Carragher, Coates, Robinson, Shelvey, Henderson, Suso, Downing, Borini.
ARSENAL v MANCHESTER CITY (Sunday 4.00)
Arsenal will assess striker Olivier Giroud's knee injury ahead of Sunday's clash with Manchester City.
Forward Gervinho is away at the African Nations Cup with Ivory Coast.
Midfielder Abou Diaby returned from three months out with a thigh problem to play for the club's under-21 side this week and could be involved against City. Defender Andre Santos (stomach muscle) also had a run-out, but is not expected to feature for the first team yet.
Manchester City travel to Arsenal without Sergio Aguero, Yaya Toure and former Gunner Samir Nasri.
Striker Aguero (hamstring) remains on the sidelines while midfielder Toure is at the African Nations Cup - along with brother Kolo, the defender, and back-up striker Abdul Razak - and forward Nasri completes a three-game suspension.
Left-back Aleksandar Kolarov (knee) is back in contention for the Barclays Premier League clash at the Emirates Stadium but right-back Maicon (knee) is still out while Micah Richards and Jack Rodwell are long-term casualties.
Arsenal squad: Szczesny, Gibbs, Vermaelen, Mertesacker, Sagna, Podolski, Cazorla, Wilshere, Oxlade-Chamberlain, Arteta, Walcott, Mannone, Giroud, Ramsey, Koscielny, Rosicky, Coquelin, Arshavin, Jenkinson, Diaby.
Manchester City squad: Hart, Pantilimon, Zabaleta, Kompany, Nastasic, Lescott, Kolarov, Clichy, Rekik, Milner, Barry, Garcia, Sinclair, Silva, Tevez, Dzeko, Balotelli, Lopes, Suarez.