The Greek side play in green and white and have a shamrock on their jersey but there is no Irish connection with Henk Ten Cate's side.
Probably the most famous of Greek sides, Panathinaikos play out of the Olympic Stadium in Athens, with a capacity of over 70,000, although the home ground they will always be associated with is the Apostolos Nikolaidis Stadium.
The Shamrocks' best European adventure came in 1971 when they reached the European Cup final, only to lose 2-0 to Ajax at Wembley Stadium.
Coach: Henk Ten Cate
The former Chelsea coach took over at Panathinaikos at the start of the 2008 season after an instantly forgettable season as Avram Grant's assistant at Chelsea.
The former Barcelona assistant manager took over Ajax in 2006 before being head-hunted by the London club. However, Ten Cate was shown the Stamford Bridge door soon after their Champions League final defeat to Manchester United.
Ten Cate's most successful period to date was the three years at Barcelona where he was Frank Rijkaard's assistant. During that time, Barca won the Champions League and two Spanish titles.
One to watch: Gilberto Silva
Only time will tell what influence the Brazil international will have as the Greek side look to re-establish themselves in Europe.
Considered surplus to requirements at Arsene Wenger's youthful Arsenal, the 31-year-old still has plenty to offer and remains a part of Brazil's squad for the 2010 World Cup qualifiers.
Gilberto's defensive midfield work will make Panathinaikos a tough team to score against but it is unlikely that the Brazilian's influence will be enough to help them qualify for the knock-out stages this time around.