Cristiano Ronaldo underwent a successful operation on his right ankle on Monday, Manchester United have announced.
The Portuguese winger had a procedure in Amsterdam carried out by a Dutch surgeon, but the club say they will not be able to state when he will be fit again until he is seen by the specialist in a month.
It is likely he will be out for at least six weeks and miss the start of the new season.
United said in a statement:
'Cristiano Ronaldo underwent surgery today to his right ankle.
'The operation was performed by Professor C. Niek van Dijk at The Academic Medical Centre in Amsterdam and the initial indications are that the procedure was successful.
'Cristiano will begin his convalescence under the direction of club medical staff and an estimation of his return to full fitness will be possible following review by the specialist in one month.'
It will further cool speculation that the Portugese midfielder is set for a move to Real Madrid.
In the ongoing Ronaldo transfer saga, Real Madrid president Ramon Calderon has admitted there was no more that could be done to lure the winger to the Bernabeu.
Calderon will meet United chief executive David Gill on Monday, where it is expected the Barclays Premier League side will issue an official 'hands off' warning to Real.
And if that proves to be the case, it could finally mark the end of the Spaniards' protracted hunt for the Portugal international's signature.
'He must love Manchester,' Calderon told Marca.
'Once Manchester decide they want to sell and they tell us this, then we will say that we're talking about a transfer. But today that's not happening and therefore this is a situation that may end up as it is now, as nothing, and Cristiano Ronaldo will continue at Manchester next year.
'At the moment, that's the most likely scenario. They (United) don't want to sell so we can't do anything.'
Calderon admitted he held out some hope of bringing Ronaldo to the Spanish capital, adding there may be time to convince United to change their mind before the August 31 transfer deadline.
'Theoretically there's still time (for things to change),' he continued.
'There are two months left until the end of August if Manchester get in touch with Real Madrid and make us an offer. But still we don't know if it would be possible to buy him even if they did want to sell.'
Reports in Spain suggested United were set to test Real's resolve by offering Ronaldo for around £#80million - nearly £12million more than the £67million Real were reportedly prepared to pay.
Calderon admitted, for a player of Ronaldo's calibre, such sums were not out of the question, but insisted the figure was only speculation as the two clubs had never discussed terms.
'This is speculation which may be reasonable given what has happened in the major transfers in football history,' he said.
'But we never got round to talking about amounts of money because Manchester never gave us the opportunity to do so.
'He (Ronaldo) said that he would like, that it is his dream, that he would be extremely excited to come to play for Real Madrid, but it is a desire of the player that cannot be realised without Manchester's consent.'