Nemanja Vidic is a doubt for Manchester United's FA Cup replay with Reading.
The Serbian defender missed training on Monday as he was still feeling the after effects of tough games against Lille and Fulham and seems certain to miss the trip to the Madejski Stadium as the Red Devils look to book a quarter-final meeting with Middlesbrough or West Brom.
With a key Premiership trip to Liverpool looming at the weekend, more changes are likely with Ryan Giggs, Paul Scholes, Edwin van der Sar and Henrik Larsson among those who could be rested, while Alan Smith is likely to make an appearance from the bench.
Reading defender Andre Bikey returns from suspension.
January signings Michael Duberry and Greg Halford are cup-tied but striker Kevin Doyle is back in the squad following a hamstring injury.
Manager Steve Coppell has used cup games as an opportunity to field fringe players, so major changes from Saturday's 2-1 defeat at Middlesbrough are expected.
Reading squad: Federici, De La Cruz, Ingimarsson, Bikey, Sodje, Gunnarsson, Shorey, Oster, Seol, Sidwell, Harper, Little, Kitson, Long, Lita, Doyle, Hahnemann, Murty.
Man Utd squad: Van der Sar, Kuszczak, Heaton, Neville, Brown, Ferdinand, Vidic, Silvestre, O'Shea, Evra, Heinze, Ronaldo, Park, Scholes, Carrick, Fletcher, Giggs, Richardson, Larsson, Saha, Rooney, Solskjaer, Smith.
