Cleveland Police have confirmed three Middlesbrough fans were stabbed and 10 others injured during violent clashes with Roma supporters last night.
The two teams meet in the Eternal City tonight as Middlesbrough look to secure a UEFA Cup quarter-final place.
Boro hold a 1-0 lead from the first leg but preparations for tonight's return match in Italy have been marred by trouble in Rome.
Middlesbrough chief executive Keith Lamb has confirmed several fans were hospitalised after being attacked by Roma fans.
Lamb told BBC Radio Five Live there had been a violent incident last night.
"There was an incident in one of the bars in a square in Rome. Some Boro fans were drinking in a bar and the bar was attacked by some Roma fans," he said.
"A number of Boro fans have been injured - a small number - and taken to hospital and received medical treatment.
"As far as I'm aware everybody is okay now, although one was retained in hospital but is in a stable condition."